Table 2 Hazard ratios of mortality by different levels of osteocalcin at baseline and during follow-up among patients with type 2 diabetes
| Â | Osteocalcin (ng/mL) | ||||
|---|---|---|---|---|---|
Quintile 1 | Quintile 2 | Quintile 3 | Quintile 4 | Quintile 5 | |
All-cause mortality | |||||
 Baseline value | |||||
  No. of participants | 1890 | 1879 | 1885 | 1878 | 1881 |
  No. of cases | 579 | 290 | 210 | 182 | 377 |
  Person-years | 9557 | 9813 | 10,359 | 10,489 | 10,320 |
  Age- and sex-adjusted HR | 2.68 (2.26–3.17) | 1.59 (1.32–1.92) | 1.15 (0.95–1.41) | 1.00 | 2.19 (1.84–2.62) |
  Multivariable adjusted HR | 2.88 (2.42–3.42) | 1.65 (1.37–1.99) | 1.17 (0.96–1.42) | 1.00 | 1.92 (1.60–2.30) |
 Mean value | |||||
  No. of participants | 1884 | 1883 | 1884 | 1882 | 1880 |
  No. of cases | 386 | 346 | 329 | 283 | 294 |
  Person-years | 9881 | 10,204 | 10,316 | 10,058 | 10,079 |
  Age- and sex-adjusted HR | 1.26 (1.06–1.50) | 1.21 (1.01–1.45) | 1.13 (0.95–1.36) | 1.00 | 1.08 (0.92–1.27) |
  Multivariable adjusted HR | 1.26 (1.08–1.54) | 1.22 (1.01–1.46) | 1.16 (0.97–1.38) | 1.00 | 1.07 (0.91–1.27) |
CVD mortality | |||||
 Baseline value | |||||
  No. of participants | 1890 | 1879 | 1885 | 1878 | 1881 |
  No. of cases | 232 | 115 | 62 | 61 | 118 |
  Person-years | 9557 | 9813 | 10,359 | 10,489 | 10,320 |
  Age- and sex-adjusted HR | 3.19 (2.40–4.24) | 1.89 (1.38–2.58) | 1.01 (0.71–1.44) | 1.00 | 1.98 (1.45–2.70) |
  Multivariable adjusted HR | 3.52 (2.63–4.71) | 2.00 (1.46–2.73) | 1.03 (0.72–1.47) | 1.00 | 1.67 (1.21–2.31) |
 Mean value | |||||
  No. of participants | 1884 | 1883 | 1884 | 1882 | 1880 |
  No. of cases | 146 | 119 | 118 | 107 | 98 |
  Person-years | 9881 | 10,204 | 10,316 | 10,058 | 10,079 |
  Age- and sex-adjusted HR | 1.57 (1.17–1.10) | 1.24 (0.92–1.68) | 1.23 (0.90–1.69) | 1.00 | 0.93 (0.70–1.22) |
  Multivariable adjusted HR | 1.64 (1.22–2.21) | 1.28 (0.94–1.74) | 1.27 (0.92–1.74) | 1.00 | 0.92 (0.70–1.22) |