Choroidal thickness and granulocyte colony-stimulating factor in tears improve the prediction model for coronary artery disease

Romero-Trevejo, José Lorenzo; Fernández-Romero, Lourdes; Delgado, Josué; Muñoz-García, Erika; Sánchez-Pérez, Andrés; Murri, Mora; Gutiérrez-Bedmar, Mario; Jiménez-Navarro, Manuel Francisco

doi:10.1186/s12933-022-01538-0

Cardiovascular Diabetology

Table 2 Comparative study for the measured clinical and laboratory ophthalmological variables

From: Choroidal thickness and granulocyte colony-stimulating factor in tears improve the prediction model for coronary artery disease

Variable	Without coronary lesions	n	With coronary lesions	n	p (Student’s t-test)
BCVA	0.95 ± 0.13	54	0.97 ± 0.07	134	0.36
IOP	15.13 ± 3.93	54	14.88 ± 3.11	136	0.64
ST	16.24 ± 10.28	54	15.20 ± 9.87	138	0.52
TCCT	546.28 ± 32.61	50	553.16 ± 37.76	126	0.26
PCCT	543.08 ± 32.95	52	549.79 ± 36.54	130	0.25
AL	23.35 ± 1.48	54	23.77 ± 1.16	120	0.04
CMT	261.24 ± 22.77	54	267.33 ± 26.10	132	0.14
MCV	10.14 ± 0.39	54	10.14 ± 0.56	132	0.97
MMT	281.54 ± 10.83	54	281.44 ± 15.46	132	0.97
RNFLT	89.54 ± 9.72	54	89.31 ± 12.39	131	0.90
GCLT	81.20 ± 8.44	54	79.73 ± 10.84	133	0.37
GCLMT	76.63 ± 12.19	54	74.14 ± 17.36	133	0.34
CT	260.74 ± 44.00	54	308.29 ± 69.92	131	< 0.001
ILM	20.68 ± 4.29	41	20.70 ± 5.40	52	0.99
RNFL-GCL	21.27 ± 4.32	41	21.45 ± 5.69	52	0.87
GCL-IPL	26.08 ± 4.71	41	25.86 ± 5.73	52	0.85
IPL-INL	32.64 ± 5.73	41	30.98 ± 5.52	52	0.16
IL-1β	0.38 ± 0.19	39	0.45 ± 0.81	92	0.60
IL-1RA	4723.71 ± 2361.33	34	4539.61 ± 2158.62	95	0.68
IL-4	0.37 ± 0.21	44	0.35 ± 0.16	102	0.45
IL-5	4.60 ± 2.75	12	3.66 ± 1.50	30	0.16
IL-6	2.54 ± 3.34	43	2.29 ± 4.00	102	0.73
IL-7	4.85 ± 2.03	45	5.01 ± 2.26	106	0.69
IL-8	112.42 ± 141.78	45	66.68 ± 87.25	107	0.02
IL-9	4.57 ± 3.38	29	4.84 ± 3.06	59	0.70
IL-13	0.43 ± 0.25	25	0.40 ± 0.21	75	0.60
IL-17	2.37 ± 0.97	2	2.10 ± 1.80	14	0.85
EO	0.62 ± 0.23	45	0.58 ± 0.22	107	0.24
G-CSF	44.38 ± 53.10	25	20.98 ± 29.01	59	0.01
GM-CSF	0.58 ± 0.28	28	0.62 ± 0.28	75	0.57
IFN-γ	65.86 ± 23.69	45	58.62 ± 24.41	107	0.09
IP-10	2062.35 ± 1174.51	42	2338.23 ± 1109.79	100	0.19
MCP-1	21.67 ± 20.85	45	13.72 ± 16.48	107	0.01
MIP-1α	0.74 ± 1.51	45	0.39 ± 0.61	106	0.05
PDGF-BB	19.49 ± 11.51	18	21.16 ± 11.49	35	0.62
MIP-1β	4.06 ± 3.92	42	4.25 ± 6.68	97	0.87
RANTES	22.36 ± 15.69	45	33.85 ± 27.22	107	0.009
TNF-α	13.26 ± 11.69	13	13.38 ± 11.38	25	0.98

Data are shown as mean ± standard deviation. Statistically significant results are shown in bold (p<0.05).
n Number of eyes; BCVA Best corrected visual acuity; IOP Intraocular pressure; ST Schirmer’s test; TCCT Topography central corneal thickness; PCCT Pachymetry central corneal thickness; AL Axial length; CMT Central macular thickness; MCV Macular cube volume; MMT Mean macular thickness; RNFLT Retinal nerve fibre layer thickness; GCLT Ganglion cell layer thickness; GCLMT Ganglion cell layer minimun thickness; CT Choroidal thickness; ILM Central vascular density under the inner limiting membrane; RNFL-GCL Central vascular density between retinal nerve fibre layer and ganglion cell layer; GCL-IPL Central vascular density between ganglion cell layer and inner plexiform layer; IPL-INL Central vascular density between inner plexiform layer and inner nuclear layer; IL Interleukin; EO Eotaxin; G-CSF Granulocyte colony-stimulating factor; GM-CSF Granulocyte–macrophage colony-stimulating factor; IFN Interferon; IP Chemokine; MCP Monocyte chemoattractant protein; MIP Macrophage inflammatory protein; PDGF Platelet-derived growth factor; RANTES Chemokine ligand 5; TNF Tumour necrosis factor

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ISSN: 1475-2840

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