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Table 2 Comparison of AGEs, sRAGE isoforms, and their ratios between healthy controls (CTR) and patients with type 2 diabetes

From: Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study

 

CTR (n = 125)

Type 2 diabetes (n = 362)

P-value

sRAGE (pg/mL)

430.6 (275.0–595.9)

667.7 (464.8–929.9)

 < 0.001

esRAGE (pg/mL)

242.9 (153.9–362.3)

283.5 (138.0–432.9)

0.312

cRAGE (pg/mL)

149.0 (44.7–267.8)

324.1 (173.7–521.0)

 < 0.001

AGEs (µg/ml)

4.41 (2.45–6.23)

11.15 (4.43–21.40)

 < 0.001

AGEs/sRAGE

0.009 (0.005–0.018)

0.017 (0.006–0.035)

 < 0.001

AGEs/esRAGE

0.016 (0.010–0.026)

0.055 (0.024–0.099)

 < 0.001

AGEs/cRAGE

0.030 (0.011–0.103)

0.036 (0.011–0.095)

0.914

  1. Data are median (IQR)
  2. P-values for Mann–Whitney U test. Significant differences are in bold
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Cardiovascular Diabetology

ISSN: 1475-2840