Fig. 2

Graphical summary of length two disease trajectories. Chord diagrams displaying the directional relations for selected directional diagnosis pairs. ICD-10 codes that comprise directional pairs are marked in the periphery and ribbons indicate directional diagnosis pairs. Width of ribbons corresponds to the number of patients that follow a directional diagnosis pair. A The 35 directional diagnosis pairs followed by most patients that contain at least one ICD-10 code for IHD. Number of patients represented: 469,342. Diagnosis D1 refers to the diagnosis that appears first (youngest age) and diagnosis D2 refers to the diagnosis D2 (oldest age) in the directional diagnosis pair as indicated in the insert on right. B All directional diagnosis pairs that did not contain an ICD-10 code for IHD and followed by more than 20,000 patients. Number of patients represented: 355,921. Number of directional diagnosis pairs: 63. Diagnoses D1 and D2 are indicated as they are in A. A and B: Number of distinct patients in A and B: 331,207. Only directional diagnoses pairs without Y99 (death) and more than three months between estimated age at D1 and D2 are depicted. Color key according to ICD-10 chapter and available in Additional file 1: Figure S3. IHD: Ischemic heart disease. ICD-10: International Statistical Classification of Disease and Health Related Problems 10th Revision. For a full list of ICD-10 codes and descriptions see Additional file 1: Table S1