Table 5 Multivariable Cox regression analyses of PCSK9 levels for clinical outcomes
Events | PCSK9 (ng/mL) | Unadjusted | Multivariate adjusted* | |||
|---|---|---|---|---|---|---|
≤ 43.5 | > 43.5 |  HR (95% CI) | P | HR (95% CI) | P | |
Whole cohort | n = 514 | n = 513 |  |  |  |  |
 MACEs | 67 (13.0) | 88 (17.2) | 1.420 (1.033–1.953) | 0.031 | 1.361 (0.964–1.923) | 0.080 |
 All-cause death | 26 (5.1) | 36 (7.0) | 1.443 (0.870–2.392) | 0.155 | 1.312 (0.730–2.358) | 0.364 |
 Recurrent myocardial infarction | 18 (3.5) | 23 (4.5) | 1.364 (0.736–2.532) | 0.324 | 1.357 (0.720–2.558) | 0.345 |
 Ischemic stroke | 17 (3.3) | 20 (3.9) | 1.305 (0.683-2.500) | 0.419 | 1.302 (0.668–2.538) | 0.437 |
 Rehospitalization for heart failure | 7 (1.4) | 16 (3.1) | 2.463 (1.011–5.988) | 0.047 | 1.550 (0.597–4.032) | 0.368 |
DM | n = 136 | n = 141 |  |  |  |  |
 MACEs | 16 (11.8) | 30 (21.3) | 2.200 (1.195–4.048) | 0.011 | 2.283 (1.094–4.764) | 0.028 |
 All-cause death | 5 (3.7) | 14 (9.9) | 3.021 (1.086–8.403) | 0.034 | 2.646 (0.774–9.091) | 0.121 |
 Recurrent myocardial infarction | 1 (0.7) | 8 (5.7) | 9.174 (1.134–71.429) | 0.038 | - | – |
 Ischemic stroke | 9 (6.6) | 8 (5.7) | 1.017 (0.391–2.646) | 0.972 | 1.004 (0.351–2.873) | 0.993 |
 Rehospitalization for heart failure | 1 (0.7) | 3 (2.1) | 3.802 (0.387–37.037) | 0.252 | – | – |
Non-DM | n = 378 | n = 372 |  |  |  |  |
 MACEs | 51 (13.5) | 58 (15.6) | 1.207 (0.828–1.759) | 0.329 | 1.145 (0.764–1.718) | 0.512 |
 All-cause death | 21 (5.6) | 22 (5.9) | 1.091 (0.560–1.984) | 0.776 | 1.125 (0.548–2.257) | 0.769 |
 Recurrent myocardial infarction | 17 (4.5) | 15 (4.0) | 0.926 (0.462–1.855) | 0.828 | 0.926 (0.454–1.883) | 0.829 |
 Ischemic stroke | 8 (2.1) | 12 (3.2) | 1.650 (0.674–4.049) | 0.273 | 1.742 (0.694–4.367) | 0.237 |
 Rehospitalization for heart failure | 6 (1.6) | 13 (3.5) | 2.273 (0.863–5.988) | 0.097 | 1.748 (0.617–4.950) | 0.293 |