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Table 3 Subgroup analysis of the association of CT-proET-1 and MR-proADM with incident type 2 diabetes

From: Associations of the vasoactive peptides CT-proET-1 and MR-proADM with incident type 2 diabetes: results from the BiomarCaRE Consortium

 

N cases/PY

CT-proET-1

MR-proADM

 

Hazard ratio [95%CI]

P-interaction

Hazard ratio [95%CI]

P-interaction

Overall

862/149,937

1.10 [1.03; 1.18], P = 0.008

 

1.11 [1.02; 1.21], P = 0.016

 

BMI (kg/m2)

  

0.020

 

 < 0.001 a

 Obese (≥ 30)

420/22,897

1.09 [0.99; 1.20], P = 0.070

 

1.19 [1.05; 1.34], P = 0.005

 

 Non-obese (< 30)

442/127,040

1.11 [1.00; 1.24], P = 0.058

 

1.02 [0.90; 1.15], P = 0.741

 

Waist circumference (cm)

  

0.348

 

0.001 a

 Obese (Men: ≥ 102, Women: ≥ 88)

470/30,126

1.09 [1.00; 1.20], P = 0.055

 

1.15 [1.03; 1.28], P = 0.013

 

 Non-obese (Men: < 102, Women: < 88)

392/119,811

1.10 [0.98; 1.24], P = 0.116

 

1.01 [0.88; 1.15], P = 0.909

 

Sex

  

0.145

 

0.157

 Men

615/91,156

1.07 [0.97; 1.17], P = 0.164

 

1.06 [0.96; 1.19], P = 0.257

 

 Women

247/58,781

1.19 [1.05; 1.35], P = 0.006

 

1.25 [1.08; 1.46], P = 0.004

 

Actual hypertensionb

  

0.161

 

0.374

 Yes

608/60,423

1.10 [1.01; 1.19], P = 0.026

 

1.12 [1.02; 1.24], P = 0.023

 

 No

254/89,513

1.16 [0.99; 1.35], P = 0.069

 

1.10 [0.93; 1.30], P = 0.267

 
  1. The associations were computed using Cox regression models per 1-SD increment of log (MR-proADM) and CT-proET-1
  2. The models included study cohort as a stratum variable and were adjusted for age (continuous, in years), sex (men/women), actual hypertension (yes/no), total and HDL cholesterol (continuous, in mmol/l), current smoking status (yes/no) and BMI (continuous, in kg/m2) (waist circumference (continuous, in cm) instead of BMI in models for waist circumference)
  3. Actual hypertension was defined as having systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg or using antihypertensive medication
  4. BMI body mass index, CI confidence interval, CT-proET-1 C-terminal-proendothelin-1, MR-proADM mid-regional-proadrenomedullin, PY person-years
  5. aRemained significant (FDR < 0.05) after correcting for multiple testing with the Benjamini–Hochberg method
  6. bActual hypertension was defined as systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg or using antihypertensive medication
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Cardiovascular Diabetology

ISSN: 1475-2840