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Table 1 Participant characteristics in the total study population and stratified by incident type 2 diabetes status

From: Associations of the vasoactive peptides CT-proET-1 and MR-proADM with incident type 2 diabetes: results from the BiomarCaRE Consortium

 

Overall

Incident type 2 diabetes

Cases

Non-cases

Number of individuals

12,006

862

11,144

Cohort (N (%))

   

 FINRISK

7336 (61.1)

531 (61.6)

6805 (61.1)

 PRIME Belfast

2496 (20.8)

240 (27.8)

2256 (20.2)

 KORA F4

2174 (18.1)

91 (10.6)

2083 (18.7)

CT-proET-1, in pmol/l [mean (SD)]

50.7 (13.4)

55.5 (14.2)

50.3 (13.3)

MR-proADM, in nmol/l [geometric mean (antilog SD)]

0.46 (1.31)

0.52 (1.30)

0.45 (1.30)

Age, in years [mean (SD)]

49.4 (11.8)

54.7 (9.2)

49.0 (11.8)

Male [N (%)]

7072 (58.9)

615 (71.3)

6457 (57.9)

Body mass index, in kg/m2 [mean (SD)]

26.5 (4.25)

30.6 (5.04)

26.1 (4.01)

Waist circumference, in cm [mean (SD)]

88.9 (12.8)

101 (12.9)

87.9 (12.3)

Actual hypertension [N (%)]a

4899 (40.8)

608 (70.5)

4,291 (38.5)

Systolic blood pressure, in mmHg [mean (SD)]

132.1 (20.1)

144.0 (20.7)

131.2 (19.8)

Diastolic blood pressure, in mmHg [mean (SD)]

81.0 (11.3)

87.2 (11.4)

80.5 (11.2)

Use of antihypertensive medication [N (%)]

1,308 (10.9)

225 (26.1)

1,083 (9.7)

Current smoker [N (%)]

3,234 (26.9)

234 (27.1)

3,000 (26.9)

Total cholesterol, in mmol/l [mean (SD)]

5.59 (1.05)

5.89 (1.06)

5.56 (1.05)

HDL, in mmol/l [mean (SD)]

1.37 (0.37)

1.19 (0.33)

1.39 (0.37)

eGFR (ml/min/1.73m2) [mean (SD)]

89.1 (19.4)

84.8 (21.3)

89.4 (19.2)

Insulin (microU/ml) [geometric mean (antilog SD)]

5.79 (1.85)

9.04 (1.89)

5.60 (1.82)

hsCRP (mg/l) [geometric mean (antilog SD)]

1.23 (3.03)

2.19 (2.83)

1.18 (3.01)

Leptin (ng/ml) [geometric mean (antilog SD)]

7.30 (2.69)

11.07 (2.52)

7.07 (2.69)

Fasting glucose (mmol/l) [geometric mean (antilog SD)]b

5.01 (1.13)

5.45 (1.23)

4.98 (1.12)

  1. Data are presented as frequency (percentage) for categorical variables and as mean (SD) for continuous variables. Continuous variables with skewed distributions are presented as geometric mean (antilog SD)
  2. CT-proET-1 C-terminal-proendothelin-1, eGFR estimated glomerular filtration rate, HDL high-density lipoprotein, hsCRP high-sensitivity C-reactive protein, KORA Cooperative Health Research in the Region of Augsburg Study, MR-proADM mid-regional-proadrenomedullin, PRIME Prospective Epidemiological Study of Myocardial Infarction, SD standard deviation
  3. aActual hypertension was defined as having systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg or using antihypertensive medication
  4. bData were available and calculated in 9112 participants of FINRISK and KORA F4 who fasted at least 4 h (593 cases and 8519 non-cases of incident type 2 diabetes)
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Cardiovascular Diabetology

ISSN: 1475-2840