Prediabetes and insulin resistance in a population of patients with heart failure and reduced or preserved ejection fraction but without diabetes, overweight or hypertension

Table 2 Comparisons of the indexes of insulin resistance in HF groups and in the control group

	HF patients			p	Controls	p*
	Total HF	HFrEF	HFpEF		Controls
	(n = 190)	(n = 114)	(n = 76)		(n = 95)
HOMA-IR	4.10 ± 3.70	4.51 ± 3.89	3.49 ± 3.31	< 0.0001	1.86 ± 1.01	< 0.0001
I₀/G₀	2.34 [6.40–17.76]	2.37 [1.10–4.75]	2.12 [0.89–4.05]	0.882	1.80 [1.10–2.60]	0.146
I₂/G₂	11.18 [6.40–17.76]	11.60 [6.46–19.56]	9.76 [6.29–16.08]	0.183	7.10 [3.60–13.00]	< 0.0001
QUICKI	0.63 ± 0.25	0.61 ± 0.27	0.65 ± 0.23	0.416	0.65 ± 0.11	0.452
ISIT0	8.53 [4.02–21.45]	7.89 [3.50–20.17]	9.74 [5.03–27.03]	0.079	14.19 [9.03–22.05]	< 0.0001
ISIT120	0.76 [0.47–1.63]	0.70 [0.44–1.68]	0.96 [0.53–1.63]	0.213	1.72 [0.83–3.73]	< 0.0001
FIRI	2.60 [1.04–5.53]	2.81 [1.10–6.36]	2.28 [0.82–4.41]	0.079	1.57 [1.01–2.46]	< 0.0001

FIRI fasting insulin resistance index; I₀/G₀ plasma insulin/glucose ratio measured at fasting; I₂/G₂ plasma insulin/glucose ratio measured 2 h after glucose intake; HOMA-IR homeostatic model assessment of insulin resistance; ISIT0 fasting insulin sensitivity index; ISIT120 2 h-insulin sensitivity index; QUICKI quantitative insulin-sensitivity check index
p: comparisons between HFrEF and HFpEF
p*: comparisons between the total HF group and control group

ISSN: 1475-2840