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Table 1 Comorbidities and admission medical therapy

From: Infarct size, inflammatory burden, and admission hyperglycemia in diabetic patients with acute myocardial infarction treated with SGLT2-inhibitors: a multicenter international registry

 

Total

(N = 583)

SGLT2-I

users

(N = 98)

Non-SGLT-I

users

(N = 485)

p value

Age, n (%)

71 [61–79]

65 [58–74]

72 [62–80]

< 0.001

Male Sex, n (%)

444 (76.2)

80 (81.6)

364 (75.1)

0.163

BMI, Kg/m2

28.3 ± 4.9

28.2 ± 4.9

28.4 ± 5

0.577

BSA, m2

1.9 ± 0.2

1.9 ± 0.3

1.9 ± 0.2

0.145

Smoking, n (%)

337 (57.8)

62 (63.3)

275 (56.7)

0.230

Hypertension, n (%)

485 (83.2)

87 (88.8)

398 (82.1)

0.105

Dyslipidemia, n (%)

460 (78.9)

84 (85.7)

376 (77.5)

0.07

PAD, n (%)

70 (12)

13 (13.3)

57 (11.8)

0.674

COPD, n (%)

78 (13.4)

13 (13.3)

65 (13.4)

0.971

CKD, n (%)

51 (8.7)

8 (8.2)

43 (8.9)

0.822

Previous TIA/CVA, n (%)

46 (7.9)

9 (9.2)

37 (7.6)

0.603

Previous AMI, n (%)

152 (26.1)

29 (29.6)

123 (25.4)

0.384

Previous PCI, n (%)

166 (28.5)

33 (33.7)

133 (27.4)

0.211

AF, n (%)

53 (9.1)

9 (9.2)

44 (9.1)

0.972

Antiplatelets, n (%)

293 (50.3)

52 (53.1)

241 (49.7)

0.543

Anticoagulation, n (%)

50 (8.6)

5 (5.1)

45 (9.3)

0.178

RAAS-I, n (%)

330 (56.6)

64 (65.3)

266 (54.8)

0.07

Diuretics, n (%)

170 (32)

26 (26.5)

144 (29.7)

0.820

B-blockers, n (%)

255 (43.7)

47 (48)

208 (42.9)

0.356

CCB, n (%)

156 (26.8)

22 (22.4)

134 (27.6)

0.291

Statins, n (%)

284 (48.7)

54 (55.1)

230 (47.4)

0.165

 Low/moderate intensity

203 (71.5)

35 (64.8)

173 (75.2)

0.120

 High intensity

81 (28.5)

19 (35.2)

57 (24.8)

 

 Ezetimibe, n (%)

70 (12)

13 (13.3)

57 (11.8)

0.674

Metformin, n (%)

420 (72)

72 (73.5)

348 (71.8)

0.730

Sulfonylureas, n (%)

157 (26.9)

12 (12.2)

145 (30)

0.001

DPP-4 Inhibitors, n (%)

47 (8.1)

7 (7.1)

40 (8.2)

0.714

GLP-1 Agonist, n (%)

14 (2.4)

3 (3.1)

11 (2.3)

0.640

  1. Continuous variables are presented as mean ± SD or as median [IQR]; categorical variables as number (%). BMI:  Body Mass Index; BSA:  Body Surface Area; PAD: peripheral arterial disease; COPD: Chronic obstructive pulmonary disease; CKD: Chronic kidney disease with 30 < GFR < 60 ml/min; PCI:  Percutaneous Coronary Intervention; AF: Atrial fibrillation; RAAS-I: Renin-angiotensin-aldosterone system inhibitors; CCB: Calcium Channel Blockers; DPP-4: Dipeptidyl Peptidase 4; GLP-1: Glucagon-like peptide-1