Table 2 Comorbidities among patients with T1DM who had a non-traumatic lower extremity amputation (Spain 2001–2019)
2001–06 | 2007–12 | 2013–19 | Trend | ||
|---|---|---|---|---|---|
MINOR | N | 1445 | 1123 | 1424 | 0.008 |
Peripheral arterial disease, n (%) | 1108 (76.68) | 767 (68.3) | 725 (50.91) | < 0.001 | |
Infection, n (%) | 282 (19.52) | 329 (29.3) | 332 (23.31) | < 0.001 | |
Peripheral neuropathy, n (%) | 129 (8.93) | 234 (20.84) | 412 (28.93) | < 0.001 | |
Ischemic Heart Disease, n (%) | 51 (3.53) | 49 (4.36) | 104 (7.3) | < 0.001 | |
Chronic Kidney Disease, n (%) | 217 (15.02) | 239 (21.28) | 459 (32.23) | < 0.001 | |
Hypertension, n (%) | 447 (30.93) | 399 (35.53) | 434 (30.48) | 0.013 | |
Stroke, n (%) | 56 (3.88) | 26 (2.32) | 45 (3.16) | 0.082 | |
Heart failure, n (%) | 161 (11.14) | 125 (11.13) | 187 (13.13) | 0.175 | |
Lipid metabolism disorders, n (%) | 168 (11.63) | 240 (21.37) | 434 (30.48) | < 0.001 | |
Liver disease, n (%) | 33 (2.28) | 52 (4.63) | 61 (4.28) | 0.002 | |
Dementia, n (%) | 8 (0.55) | 1 (0.09) | 8 (0.56) | 0.124 | |
Chronic pulmonary disease, n (%) | 79 (5.47) | 44 (3.92) | 79 (5.55) | 0.119 | |
Connective tissue disorder, n (%) | 9 (0.62) | 5 (0.45) | 12 (0.84) | 0.458 | |
Peptic ulcer, n (%) | 18 (1.25) | 10 (0.9) | 12 (0.84) | < 0.352 | |
Cancer or metastatic cancer, n (%) | 6 (0.42) | 9 (0.8) | 13 (0.91) | 0.250 | |
Human immunodeficiency virus, n (%) | 2 (0.14) | 1 (0.09) | 4 (0.28) | 0.473 | |
MAJOR | N | 984 | 530 | 505 | < 0.001 |
Peripheral arterial disease, n (%) | 845 (85.87) | 420 (79.25) | 309 (61.19) | < 0.001 | |
Infection, n (%) | 126 (12.8) | 113 (21.32) | 91 (18.02) | < 0.001 | |
Peripheral neuropathy, n (%) | 83 (8.43) | 87 (16.42) | 138 (27.33) | < 0.001 | |
Ischemic Heart Disease, n (%) | 89 (9.04) | 49 (9.25) | 60 (11.88) | 0.193 | |
Chronic Kidney Disease, n (%) | 162 (16.46) | 155 (29.25) | 200 (39.6) | < 0.001 | |
Hypertension, n (%) | 333 (33.84) | 189 (35.66) | 142 (28.12) | 0.024 | |
Stroke, n (%) | 93 (9.45) | 39 (7.36) | 38 (7.52) | 0.265 | |
Heart failure, n (%) | 181 (18.39) | 66 (12.45) | 103 (20.4) | 0.002 | |
Lipid metabolism disorders, n (%) | 109 (11.08) | 102 (19.25) | 144 (28.51) | < 0.001 | |
Liver disease, n (%) | 34 (3.46) | 13 (2.45) | 28 (5.54) | 0.026 | |
Dementia, n (%) | 39 (3.96) | 21 (3.96) | 14 (2.78) | 0.220 | |
Chronic pulmonary disease, n (%) | 85 (8.64) | 31 (5.85) | 32 (6.34) | 0.085 | |
Connective tissue disorder, n (%) | 0 (0.00) | 3 (0.57) | 3 (0.59) | 0.057 | |
Peptic ulcer, n (%) | 12 (1.22) | 8 (1.51) | 3 (0.59) | 0.362 | |
Cancer or metastatic cancer, n (%) | 10 (1.02) | 12 (2.26) | 4 (0.79) | 0.063 | |
Human immunodeficiency virus, n (%) | 2 (0.2) | 0 (0) | 2 (0.4) | 0.358 |