Fig. 3

Comparison of subgroup effects based on subgroup-specific rates of major adverse cardiovascular events (MACE). Subgroups were ordered from left to right by event rates in pooled data including both ACCORD and VADT studies. A Event rates in each subgroup across both treatment arms (“All”, purple), among those randomized to standard glycemic control (“Standard”, blue), and among those randomized to intensive glycemic control (“Intensive”, green). Dotted lines show the event rates of MACE in the full sample (purple), in those randomized to standard glycemic control (blue), and in those randomized to intensive glycemic control (green). B Risk differences of MACE associated with standard versus intensive glycemic control, stratified by study and subgroup with subgroups ordered from left to right by increasing MACE event rates in the full sample including pooled data from both studies. Positive risk differences reflect higher MACE and negative risk differences reflect lower MACE in intensive glycemic control compared to standard glycemic control. Blue and green dotted lines represent the average treatment effect of intensive versus standard glycemic control on MACE in the ACCORD and VADT studies, respectively