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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Heterogeneous treatment effects of intensive glycemic control on major adverse cardiovascular events in the ACCORD and VADT trials: a machine-learning analysis

Fig. 1

Summary causal tree of heterogeneous treatment effects of intensive glycemic control on all-cause mortality. Splitting variables and cut-points for each split are shown, resulting in eight terminal subgroups (N (%) represent number and proportion of participants in pooled ACCORD + VADT sample in each subgroup). Units for splitting variables are mL/min for eGFR (estimated glomerular filtration rate), mg/dL for serum glucose, kg/m2 for BMI (body-mass index), and years for age. Risk difference of MACE and 95% confidence intervals in each subgroup in the pooled sample and in each study alone shown below diagram

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