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Table 2 Odds ratios and 99% confidence intervals for association between three components of the metabolic syndrome and clinical bilirubin levels

From: Bilirubin as an indicator of cardiometabolic health: a cross-sectional analysis in the UK Biobank

Bilirubin cut-off (μmol/L)

N (men/women)

Men

Women

OR (99% CI)

P trend

OR (99% CI)

P trend

Adjusted models

WC

 Ref.

 < 10

128,981/205,724

–

 < 0.001

–

 < 0.001

 1

10–17

68,710/39,020

0.80 (0.78 to 0.83)

0.73 (0.70 to 0.75)

 2

 ≥ 17.1

15,862/8,223

0.68 (0.65 to 0.72)

0.54 (0.50 to 0.58)

TG

 Ref

 < 10

129,224/206,137

–

 < 0.001

–

 < 0.001

 1

10–17

68,802/39,078

0.65 (0.63 to 0.66)

0.62 (0.59 to 0.64)

 2

 ≥ 17.1

15,874/8,230

0.58 (0.55 to 0.60)

0.52 (0.48 to 0.56)

SBP

 Ref.

 < 10

121,051/192,488

–

 < 0.001

–

 < 0.001

 1

10–17

64,434/36,713

0.90 (0.88 to 0.93)

0.91 (0.88 to 0.94)

 2

 ≥ 17.1

14,965/7,769

0.87 (0.82 to 0.92)

0.89 (0.83 to 0.96)

DBP

 Ref.

 < 10

121,052/192,493

–

 < 0.001

–

 < 0.001

 1

10–17

64,439/36,714

1.00 (0.98 to 1.03)

0.95 (0.92 to 0.99)

 2

 ≥ 17.1

14,965/7,769

0.94 (0.89 to 0.98)

0.88 (0.83 to 0.95)

  1. Logistic regression model adjusted for age at recruitment, ethnicity, alcohol consumption, alcohol consumption frequency, smoking status, physical activity, liver enzyme (alanine transaminase), chronic diseases (heart problems and diabetes), medications (for cholesterol, blood pressure, diabetes, or exogenous hormones), qualifications, and ever use of hormones among women
  2. WC, waist circumference; TG, triglycerides; SBP, systolic blood pressure; DBP, diastolic blood pressure; OR, odds ratio; CI, confidence interval
  3. The clinical cut-off of these three components of the metabolic syndrome were: (1) WC > 102 cm in men and > 88 cm in women; (2) TG ≥ 1.7 mmol/L; (3) BP ≥ 130/85 mm Hg
  4. P-trend computed as linear contrast