Metformin and high-sensitivity cardiac troponin I and T trajectories in type 2 diabetes patients: a post-hoc analysis of a randomized controlled trial

Table 4 Random slope/random intercept models of Troponin T

Parameter effect	Optimized model		Cook’s distance
Parameter effect	Estimate [IQR]	p	Estimate [IQR]	p
Baseline (ng/L)	2.4 [1.7, 3.2]	< 0.001	2.4 [1.7, 3.2]	< 0.001
Treatment (%)	− 4.6 [− 12, 3.2]	0.242	− 4.7 [− 12, 3.1]	0.229
Time effect (%/year)	5.1 [4.1, 6.1]	< 0.001	4.8 [3.9, 5.7]	< 0.001
Time-treatment interaction (%/year)	− 1.6 [− 2.9, − 0.2]	0.021	− 1.4 [− 2.6, − 0.2]	0.023
Age (%/year)	2.3 [1.9, 2.7]	< 0.001	2.3 [1.9, 2.7]	< 0.001
Female sex (%)	− 23.4 [− 29, − 17]	< 0.001	− 23.3 [− 29, − 17]	< 0.001
Cardiovascular history (%/score unit)	5.3 [2.3, 8.4]	0.001	5.2 [2.2, 8.3]	0.001

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