Metformin and high-sensitivity cardiac troponin I and T trajectories in type 2 diabetes patients: a post-hoc analysis of a randomized controlled trial

Table 3 Random slope/random intercept models of Troponin I

Parameter effect	Optimized model		Cook’s distance
Parameter effect	Estimate [IQR]	p	Estimate [IQR]	p
Baseline (ng/L)	0.0 [− 0.3, 0.4]	0.872	− 0.1 [− 0.3, 0.3]	0.771
Treatment (%)	− 8.4 [− 18.6, 3.2]	0.150	− 11 [− 21, 0.2]	0.053
Time effect (%/year)	− 2.7 [− 0.2, − 0.0]	0.005	2.5 [0.5, 4.5]	0.012
Time-treatment interaction (%/year)	− 1.5 [− 4.2, 1.2]	0.263	− 1.0 [− 3.7, 1.7]	0.460
Age (%/year)	2.6 [2.0, 3.2]	< 0.001	2.7 [2.1, 3.3]	< 0.001
Female sex (%)	− 21 [− 30, − 12]	< 0.001	− 21 [− 30, − 12]	< 0.001
Cardiovascular history (%/score unit)	12 [7.4, 17]	< 0.001	13 [− 7.8, 18]	< 0.001

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