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Table 2 Troponin I and Troponin T—baseline, short-term (4 months) and long-term (52 months) comparisons (paired samples Wilcoxon test)

From: Metformin and high-sensitivity cardiac troponin I and T trajectories in type 2 diabetes patients: a post-hoc analysis of a randomized controlled trial

Troponin I concentrations

Treatment

Time

Observations

Concentration (ng/L) [IQR]

Statistica

p

Placebo

Baseline

188

3.0 [0.6, 25.3]

–

–

4 months

179

2.9 [0.7, 45.3]

17,078

0.804

52 months

132

3.3 [0.6, 45.8]

17,926

0.589

Metformin

Baseline

194

3.6 [0.9, 26.2]

–

–

4 months

179

3.3 [0.7, 24.9]

11,717

0.396

52 months

126

3.4 [1.0, 31.2]

12,441

0.787

Troponin T concentrations

Treatment

Time

Observations

Concentration (ng/L) [IQR]

Statistica

p

Placebo

Baseline

191

10.0 [4.2, 30.7]

–

–

4 months

179

10.2 [4.2, 37.4]

16,311

0.446

52 months

132

12.6 [4.5, 55.1]

10,243

0.004

Metformin

Baseline

194

10.2 [4.9, 30.8]

–

–

4 months

179

10.7 [5.3, 32.0]

16,345

0.328

52 months

127

12.4 [5.2, 44.3]

9932

0.003

  1. IQR interquartile range
  2. aTest statistic used to calculate the p value