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Table 3 Predictive value of the FAR level and different glycemic metabolism status for primary endpoint and each component in univariate and multivariate analysis

From: High fibrinogen-to-albumin ratio with type 2 diabetes mellitus is associated with poor prognosis in patients undergoing percutaneous coronary intervention: 5-year findings from a large cohort

Variables

Events/subjects

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

HR (95% CI)

P value

MACCE

1099/5298

    

 FAR-H/DM

287/1116

Reference

–

Reference

–

 FAR-L/DM

248/1189

0.80 (0.67–0.95)

0.009

0.81 (0.68–0.97)

0.019

 FAR-H/Non-DM

247/1265

0.74 (0.63–0.88)

0.001

0.78 (0.66–0.93)

0.006

 FAR-L/Non-DM

317/1728

0.69 (0.59–0.81)

 < 0.001

0.75 (0.64–0.89)

0.001

All-cause mortality

206/5298

    

 FAR-H/DM

71/1116

Reference

–

Reference

–

 FAR-L/DM

44/1189

0.57 (0.39–0.84)

0.004

0.68 (0.47–1.00)

0.053

 FAR-H/Non-DM

56/1265

0.69 (0.49–0.98)

0.040

0.72 (0.50–1.03)

0.076

 FAR-L/Non-DM

35/1728

0.31 (0.21–0.47)

 < 0.001

0.41 (0.27–0.63)

 < 0.001

Cardiac mortality

125/5298

    

 FAR-H/DM

49/1116

Reference

–

Reference

–

 FAR-L/DM

27/1189

0.51 (0.32–0.82)

0.005

0.62 (0.39–1.00)

0.052

 FAR-H/Non-DM

35/1265

0.63 (0.41–0.97)

0.035

0.67 (0.43–1.05)

0.077

 FAR-L/Non-DM

17/1728

0.22 (0.13–0.38)

 < 0.001

0.30 (0.17–0.53)

 < 0.001

Non-fatal MI

310/5298

    

 FAR-H/DM

77/1116

Reference

–

Reference

–

 FAR-L/DM

67/1189

0.82 (0.61–1.10)

0.187

0.81 (0.58–1.13)

0.221

 FAR-H/Non-DM

66/1265

0.75 (0.54–1.04)

0.084

0.80 (0.57–1.12)

0.185

 FAR-L/Non-DM

100/1728

0.80 (0.58–1.11)

0.188

0.87 (0.64–1.19)

0.376

Non-fatal ischemic stroke

184/5298

    

 FAR-H/DM

48/1116

Reference

–

Reference

–

 FAR-L/DM

44/1189

0.85 (0.57–1.28)

0.447

0.92 (0.60–1.40)

0.702

 FAR-H/Non-DM

47/1265

0.86 (0.57–1.28)

0.455

0.89 (0.59–1.35)

0.593

 FAR-L/Non-DM

45/1728

0.59 (0.39–0.89)

0.011

0.70 (0.46–1.08)

0.105

Unplanned coronary revascularization

671/5298

    

 FAR-H/DM

160/1116

Reference

–

Reference

–

 FAR-L/DM

155/1189

0.90 (0.72–1.12)

0.333

0.85 (0.68–1.07)

0.165

 FAR-H/Non-DM

142/1265

0.77 (0.62–0.97)

0.024

0.79 (0.63–1.00)

0.050

 FAR-L/Non-DM

214/1728

0.84 (0.69–1.04)

0.103

0.82 (0.66–1.02)

0.070

  1. Model adjusted for age, sex, BMI, hypertension, previous MI, previous PCI, previous stroke, eGFR, LVEF, LM/three-vessel disease, and SYNTAX score
  2. MACCE major adverse cardiac and cerebrovascular events, FAR fibrinogen-to-albumin ratio, CI confidence interval, DM diabetes mellitus, MI myocardial infarction