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Table 2 Association of 1 mmol/l increase in RLP cholesterol levels with incident NODAT as determined by Cox regression analysis

From: Remnant lipoprotein cholesterol is associated with incident new onset diabetes after transplantation (NODAT) in renal transplant recipients: results of the TransplantLines Biobank and cohort Studies

  

All RTR (n = 480)

RTR with IFG excluded (n = 432)

HR [95% CI]

P value

HR [95% CI]

P value

Model 1

Crude analysis

2.27 [1.64–3.14]

 < 0.001

2.21 [1.55, 3.17]

 < 0.001

Model 2

Adjusted for age and sex

2.24 [1.62–3.11]

 < 0.001

2.18 [1.52, 3.11]

 < 0.001

Model 3

Model 2 + BMI, systolic and diastolic blood pressure

1.81 [1.29–2.53]

 < 0.001

1.72 [1.18, 2.49]

0.004

Model 4

Model 2 + eGFR and time since transplantation, acute rejection, HLA class I and II antibodies

2.34 [1.63–3.36]

 < 0.001

2.0 [1.36, 2.94]

 < 0.001

Model 5

Model 2 + UACR

2.23 [1.61, 3.09]

 < 0.001

2.17 [1.52, 3.1]

 < 0.001

Model 6

Model 2 + plasma glucose, HbA1c

1.80 [1.23–2.64]

0.002

1.72 [1.14, 2.58]

0.009

Model 7

Model 2 + HDL cholesterol, LDL cholesterol

1.68 [1.15–2.47]

0.008

1.65 [1.09, 2.51]

0.019

Model 8

Model 2 + statin use

2.23 [1.59–3.12]

 < 0.001

2.09 [1.45, 3.02]

 < 0.001

Model 9

Model 2 + smoking and alcohol use

2.33 [1.61, 3.38]

 < 0.001

2.2 [1.46, 3.3]

 < 0.001

Model 10

Model 2 + use of proliferation inhibitors, calcineurin inhibitors, tacrolimus, cyclosporine and prednisolone dose

2.14 [1.51–3.05]

 < 0.001

2.09 [1.42, 3.06]

 < 0.001

  1. IFG impaired fasting glucose, BMI body mass index, eGFR estimated glomerular filtration rate, HLA human leukocyte antigen, UACR urinary albumin-to-creatinine ratio, HDL high density lipoprotein, LDL low density lipoprotein