Lower miR-21/ROS/HNE levels associate with lower glycemia after habit-intervention: DIAPASON study 1-year later

Table 3 Characteristics of NR group

	Baseline	HI 1-yr	N paired	p-value
DBP (mm Hg)	77.1 ± 10.8	79.2 ± 9.2	19	0.4982
SBP (mm Hg)	127.6 ± 15.7	136.8 ± 11.7	19	0.0429
Cardiac frequency (bpm)	68.9 ± 8.6	69.6 ± 7.1	18	0.5594
BMI (Kg/m²)	27.1 ± 3.5	27.1 ± 3.9	19	0.8933
Waist circumference (cm)	97.7 ± 9.4	96.7 ± 12.2	17	0.4736
Woman	93.6 ± 8.8	90.1 ± 13.3	7	0.2965
Man	100.6 ± 9.2	100.9 ± 9.8	10	0.9277
RHI (a.u.)	2.4 ± 0.7	2.4 ± 0.8	16	0.7715
AI (75 bpm%)	23.8 ± 20.2	20.7 ± 19.1	17	0.9573
HRV (a.u.)	37 ± 17.5	35.3 ± 16.2	17	0.7417
SIF (fluor. unit)	2.4 ± 0.6	2.2 ± 0.5	18	0.0459
FPG (mg/dL)	105.3 ± 16.7	106.1 ± 20.3	19	0.8142
1hPG (mg/dL)	214.3 ± 46.4	228.6 ± 58.2	19	0.0745
2hPG (mg/dL)	200.8 ± 77	221.4 ± 67.9	19	0.0916
HbA1C (%)	6.5 ± 0.6	6.3 ± 0.6	19	0.1114
HbA1C (mmol)	47.7 ± 6.7	45.8 ± 6.3	19	0.1059
Col (mg/dL)	202.8 ± 33.1	204.6 ± 42.4	19	0.8262
HDL (mg/dL)	52.4 ± 15.7	54.2 ± 16.6	19	0.3269
TAG (mg/dL)	117.6 ± 47.7	131.3 ± 71.2	19	0.2416
LDL (mg/dL)	126.9 ± 27.1	124.2 ± 30.8	19	0.6712
INS (mIU/L)	19.6 ± 23.4	13.5 ± 7.2	18	0.3750*
HOMA-IR	5.3 ± 6.8	3.7 ± 2.1	17	0.4586*
m-ALB (mg/dL)	38.9 ± 97.2	17.8 ± 32.8	17	0.0714*
HNE (ug/mL)	10.1 ± 7.7	6.8 ± 5.1	17	0.1634
ADMA (ng/mL)	67.4 ± 69.9	46.1 ± 20.4	17	0.2435*
ROS (umol/min)	0.20 ± 0.02	0.21 ± 0.02	14	0.8270

miR-21: circulating microRNA-21; DBP: diastolic blood pressure; SBP: systolic blood pressure; BMI: body mass index; RHI: reactive hyperemia index; AI: augmentation index; HRV: heart rate variability; SIF: skin intrinsic fluorescence; FPG: fasting plasma glucose; 1hPG: 1-h plasma glucose; 2hPG: 2-h plasma glucose; HbA1C: glycated hemoglobin; Col: total cholesterol; HDL: high-density lipoprotein; TAG: triacylglycerol; LDL: low density lipoprotein; INS: insulinemia; HOMA-IR: homeostatic model assessment for insulin resistance; m-ALB: microalbuminuria; HNE: hydroxynonenal; ROS: reactive oxygen species
T test.; * Wilcoxon test

ISSN: 1475-2840