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Table 2 Characterization of the subjects with lower-miR-21 (Responders)

From: Lower miR-21/ROS/HNE levels associate with lower glycemia after habit-intervention: DIAPASON study 1-year later

 

Baseline

HI 1-yr

N paired

p-value

DBP (mm Hg)

76.5 ± 12.6

77.1 ± 11.7

97

0.6729

SBP (mm Hg)

129.8 ± 16.8

130.4 ± 14.1

97

0.7637*

Cardiac frequency (bpm)

70.5 ± 8.0

70.8 ± 8.6

95

0.7702*

BMI (Kg/m2)

27.5 ± 4.4

27.0 ± 4.0

96

0.0036

Waist circumference (cm)

97.2 ± 10.2

95.0 ± 9.4

91

0.0015*

RHI (a.u.)

2.415 ± 0.756

2.197 ± 0.607

92

0.0275

AI (75 bpm%)

22.0 ± 19.6

20.2 ± 19.2

91

0.4471

HRV (a.u.)

43.1 ± 47.3

35.2 ± 19.3

90

0.1595

SIF (fluor. unit)

2.255 ± 0.393

2.206 ± 0.399

95

0.4586

FPG (mg/dL)

96.1 ± 12.3

94.0 ± 10.4

97

0.1924

1hPG (mg/dL)

178.9 ± 41.8

174.7 ± 69.1

94

0.0080

2hPG (mg/dL)

149.4 ± 42.6

138.3 ± 38.7

96

0.0540*

HbA1C (%)

6.2 ± 0.4

6.0 ± 0.4

95

 < .0001

HbA1C (mmol)

44.6 ± 4.0

42.2 ± 4.1

97

 < .0001

Col (mg/dL)

206.1 ± 34.6

204.1 ± 37.1

97

0.5061*

HDL (mg/dL)

54.0 ± 13.4

56.4 ± 15.2

97

0.0081

TAG (mg/dL)

123.3 ± 61.3

118.9 ± 47.5

97

0.9806

LDL (mg/dL)

127.4 ± 30.5

123.9 ± 32.3

97

0.2220*

INS (mIU/L)

18.3 ± 21.1

14.1 ± 12.5

97

0.0007

HOMA-IR

4.4 ± 4.9

3.4 ± 3.3

96

0.0004

m-ALB (mg/dL)

14.9 ± 21.1

12.1 ± 15.7

83

0.0230

HNE (ug/mL)

8.2 ± 7.7

5.3 ± 4.1

95

 < .0001

ADMA (ng/mL)

47.5 ± 45.9

43.8 ± 22.2

62

0.1196

ROS (umol/min)

0.204 ± 0.017

0.19 ± 0.018

33

0.0045*

Women

    

 DBP (mm Hg)

72.8 ± 11.4

75.4 ± 11.5

55

0.1999

 SBP (mm Hg)

126.8 ± 17.0

130.7 ± 14.6

55

0.1471*

 Cardiac frequency (bpm)

72.4 ± 7.9

72.6 ± 9.3

53

0.9135*

 BMI (Kg/m2)

27.3 ± 4.9

26.7 ± 4.6

55

0.0337*

 Waist circumference (cm)

94.8 ± 10.1

93.1 ± 9.7

52

0.1170*

 RHI (a.u.)

2.555 ± 0.843

2.256 ± 0.649

52

0.0328

 AI (75 bpm%)

27.3 ± 19.3

24.2 ± 18.1

52

0.1943*

 HRV (a.u.)

34.4 ± 20.1

33.3 ± 19.3

51

0.3973

 SIF (fluor. unit)

2.296 ± 0.417

2.246 ± 0.369

54

0.9844

 FPG (mg/dL)

93.4 ± 12.3

92.0 ± 10.4

55

0.6405

 1hPG (mg/dL)

178.0 ± 45.4

178.3 ± 88.4

52

0.0296

 2hPG (mg/dL)

145.5 ± 47.5

138.7 ± 41.8

54

0.1536*

 HbA1C (%)

6.3 ± 0.3

6.1 ± 0.4

54

 < .0001

 HbA1C (mmol)

45.2 ± 3.6

42.7 ± 3.9

55

 < .0001

 Col (mg/dL)

211.7 ± 35.7

211.1 ± 34.1

55

0.8807*

 HDL (mg/dL)

59.0 ± 13.1

62.3 ± 15.0

55

0.0058

 TAG (mg/dL)

111.9 ± 47.8

113.9 ± 43.0

55

0.2337

 LDL (mg/dL)

130.4 ± 29.9

126.0 ± 29.8

55

0.2092*

 INS (mIU/L)

16.8 ± 18.8

11.9 ± 8.7

55

0.0002

 HOMA-IR

3.9 ± 4.0

2.7 ± 1.9

55

0.0002

 m-ALB (mg/dL)

14.3 ± 22.5

10.5 ± 11.7

46

0.0955

 HNE (ug/mL)

8.5 ± 6.6

6.0 ± 4.3

54

0.0001

 ADMA (ng/mL)

45.5 ± 39.9

43.1 ± 24.1

32

0.1642

 ROS (umol/min)

0.203 ± 0.021

0.19 ± 0.019

15

0.1366*

Men

    

 DBP (mm Hg)

81.4 ± 12.5

79.4 ± 11.6

42

0.4353*

 SBP (mm Hg)

133.7 ± 15.9

130.0 ± 13.7

42

0.1945

 Cardiac frequency (bpm)

68.0 ± 7.4

68.5 ± 7.3

42

0.7313*

 BMI (Kg/m2)

27.9 ± 3.6

27.5 ± 3.2

41

0.0691

 Waist circumference (cm)

100.6 ± 9.5

97.5 ± 8.5

39

0.0006*

 RHI (a.u.)

2.233 ± 0.586

2.121 ± 0.547

40

0.3240*

 AI (75 bpm%)

14.8 ± 17.9

14.8 ± 19.4

39

0.9883*

 HRV (a.u.)

54.4 ± 67.0

37.8 ± 19.2

39

0.1983

 SIF (fluor. unit)

2.20 ± 0.356

2.15 ± 0.435

41

0.2293

 FPG (mg/dL)

99.7 ± 11.3

96.7 ± 9.8

42

0.1801

 1hPG (mg/dL)

180.1 ± 37.4

170.2 ± 32.6

42

0.0713*

 2hPG (mg/dL)

154.5 ± 35.2

137.8 ± 34.7

42

0.0145*

 HbA1C (%)

6.2 ± 0.4

6.0 ± 0.4

41

 < .0001

 HbA1C (mmol)

43.9 ± 4.5

41.6 ± 4.2

42

 < .0001

 Col (mg/dL)

198.9 ± 32.2

194.9 ± 39.3

42

0.4210*

 HDL (mg/dL)

47.6 ± 10.9

48.6 ± 11.4

42

0.3664

 TAG (mg/dL)

138.2 ± 73.4

125.4 ± 52.7

42

0.3812

 LDL (mg/dL)

123.6 ± 31.3

121.3 ± 35.4

42

0.6266*

 INS (mIU/L)

20.2 ± 23.8

17.1 ± 15.9

42

0.2601

 HOMA-IR

5.1 ± 5.9

4.2 ± 4.4

41

0.1684

 m-ALB (mg/dL)

15.6 ± 19.5

14.0 ± 19.5

37

0.0991

 HNE (ug/mL)

7.8 ± 9.0

4.4 ± 3.5

41

 < .0001

 ADMA (ng/mL)

49.6 ± 52.0

44.6 ± 20.5

30

0.3911

 ROS (umol/min)

0.204 ± 0.014

0.189 ± 0.018

18

0.0126*

  1. Subjects after HI were characterized for lower circulating levels of miR-21
  2. miR-21: circulating microRNA-21; HI 1-yr: habit intervention of 1 year; DBP: diastolic blood pressure; SBP: systolic blood pressure; BMI: body mass index; RHI: reactive hyperemia index; AI: augmentation index; HRV: heart rate variability; SIF: skin intrinsic fluorescence; FPG: fasting plasma glucose; 1hPG: 1-h plasma glucose; 2hPG: 2-h plasma glucose; HbA1C: glycated hemoglobin; Col: total cholesterol; HDL: high-density lipoprotein; TAG: triacylglycerol; LDL: low-density lipoprotein; INS: insulinemia; HOMA-IR: homeostatic model assessment for insulin resistance; m-ALB: microalbuminuria; HNE: hydroxynonenal; ADMA: asymmetrical dimethylarginine; ROS: reactive oxygen species
  3. Wilcoxon Signed-Rank test; * Paired T-test
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Cardiovascular Diabetology

ISSN: 1475-2840