Lower miR-21/ROS/HNE levels associate with lower glycemia after habit-intervention: DIAPASON study 1-year later

Table 1 Characteristics of participants

	Baseline	HI 1-yr	N paired	p-value
Age	59.7 ± 8.8
Women (%)	57.4	55.6
DBP (mm Hg)	76.2 ± 11.5	76.5 ± 11.4	204	0.6627
SBP (mm Hg)	128.8 ± 15.4	129.4 ± 14.2	204	0.6412
Cardiac frequency (bpm)	70.3 ± 8.1	70.6 ± 8.2	201	0.9933
BMI (Kg/m²)	27.5 ± 4.3	27.2 ± 4.2	203	0.0040
Woman	27.3 ± 4.9	26.9 ± 4.9	113	0.0177
Man	27.8 ± 3.4	27.5 ± 3.2	90	0.0928
Waist circumference (cm)	97.6 ± 10.2	95.3 ± 10.2	195	< .0001
Woman	95.0 ± 10.4	93.3 ± 10.9	108	0.0127
Man	100.9 ± 9.1	97.7 ± 8.8	87	< .0001
RHI (a.u.)	2.41 ± 0.76	2.27 ± 0.68	189	0.0152*
AI (75 bpm%)	22.1 ± 19.9	21.7 ± 19.8	191	0.6636
HRV (a.u.)	39.3 ± 36.2	35.1 ± 17.6	188	0.5246
SIF (fluor. unit)	2.26 ± 0.47	2.15 ± 0.46	196	0.0059
FPG (mg/dL)	95.1 ± 14.0	94.5 ± 15.7	204	0.3941
1hPG (mg/dL)	170.9 ± 45.6	169.7 ± 61.1	196	0.7554*
2hPG (mg/dL)	141.4 ± 49.8	137.6 ± 48.9	201	0.1334*
HbA1C (%)	6.2 ± 0.4	6.0 ± 0.4	201	< .0001
HbA1C (mmol)	44.7 ± 4.6	42.1 ± 4.2	204	< .0001
Col (mg/dL)	207.7 ± 37.4	206.5 ± 36.7	204	0.9169
HDL (mg/dL)	56.0 ± 14.9	58.6 ± 16.2	207	< .0001
TAG (mg/dL)	120.6 ± 65.0	116.7 ± 53	207	0.8022
LDL (mg/dL)	127.8 ± 32.5	124.8 ± 31.2	207	0.2645
INS (mIU/L)	19.5 ± 26.4	13.5 ± 11.6	200	< .0001
HOMA-IR	4.7 ± 6.2	3.3 ± 3.4	195	< .0001
m-ALB (mg/dL)	15.0 ± 34.5	11.7 ± 16.2	184	0.0385
mir-21 (a.u)	0.035 ± 0.039	0.011 ± 0.022	116	< .0001
HNE (ug/mL)	9.1 ± 9.2	6.5 ± 5.8	130	< .0001
ADMA (ng/mL)	51.7 ± 50.9	45.5 ± 24.5	85	0.3391
ROS (umol/min)	0.204 ± 0.017	0.195 ± 0.020	48	0.0285*

N = 207 subjects of the N = 531 enrolled in the DIAPASON study were re-evaluated after 1 year of follow-up under healthy-habit intervention
miR-21: circulating microRNA-21; HI 1-yr: habit intervention of 1 year; DBP: diastolic blood pressure; SBP: systolic blood pressure; BMI: body mass index; RHI: reactive hyperemia index; AI: augmentation index; HRV: heart rate variability; SIF: skin intrinsic fluorescence; FPG: fasting plasma glucose; 1hPG: 1-h plasma glucose; 2hPG: 2-h plasma glucose; HbA1C: glycated hemoglobin; Col: total cholesterol; HDL: high-density lipoprotein; TAG: triacylglycerol; LDL: low-density lipoprotein; INS: insulinemia; HOMA-IR: homeostatic model assessment for insulin resistance; m-ALB: microalbuminuria; HNE: hydroxynonenal; ADMA: asymmetrical dimethylarginine; ROS: reactive oxygen species
Wilcoxon Signed-Rank test; * Paired T-test

ISSN: 1475-2840