Fig. 2

ROC curves of glycaemic parameters models in detecting miR-21 responders (R). A For each glycaemic parameter, a logistic model was implemented to evaluate the association with R. ROC curves were represented. Yellow-line represents ROC curve for HbA1c model, magenta-line represents ROC curve for FPG model, green-line represents ROC curve for 1hPG model and blue-line represents ROC curve for 2hPG model in discriminating between R and NR. Logistic regression models to evaluate the associations between lower miR-21 levels (at 1-yr) and glycemic parameters (baseline) were performed for predicting the effectiveness of the diet and relatives lower glycemic levels. B Best cut-offs of glycemic parameters in predicting miR-21 reduction were calculated using Youden index. Diagnostic values as sensitivity, specificity, positive and negative predicted values and positive and negative likelihood ratio were also evaluated