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Table 1 Relative risk of major adverse cardiac events (MACE), target lesion revascularization (TLR), and stent thrombosis (ST) in patients with and without DM undergoing PCI with second-generation drug-eluting stent (DES)

From: Diabetes and restenosis

Study

Study design

Number of diabetic patients

Total patients

T1DM and/or T2DM

Outcome

Relative risk (95% confidence interval)

P-value

References

Konishi et al. (2016)

Observational cohort study

Mean follow-up: 958 days

575

1667

T1DM

MACE

1.18 (0.74–1.82)*

0.48

[145]

199

1291

T2DM

MACE

1.07 (0.77–1.49)*

0.67

575

1667

T1DM

TLR

1.92 (1.10–3.29)*

0.02

199

1291

T2DM

TLR

1.52 (0.97–2.35)*

0.06

D'Ascenzo et al. (2017)

Retrospective multicenter study

Mean follow-up: 650 days

485

1270

T1DM

TLR

2.0 (1.1–3.6)

0.04

[146]

Honda et al. (2015)

Retrospective single center study

Mean follow-up: 23.1 months

713

1669

Both

TLR

1.23 (0.89–1.69)

0.21

[147]

Zheng et al. (2019)

Retrospective single center study

Mean follow-up: 325 days and 772 days

133

394

Both

Early TLR

2.58 (1.29–5.15)

0.007

[148]

Late TLR

1.56 (0.47–5.21)

0.472

Pi et al. (2018)

Retrospective multicenter study

Mean follow-up: 3 years

1786

4812

Both

TLR

1.70 (1.22–2.36)

0.002

[149]

ST

1.55 (0.75–3.21)

0.242

Kuramitsu et al. (2019)

Retrospective multicenter study

Mean follow-up: 4 years

695

1541

Both

Early ST

1.20 (0.81–1.77)

0.36

[150]

Late ST

1.02 (0.52–1.99)

0.95

Very late ST

0.93 (0.51–1.71)

0.83

  1. Early TLR and late LTR were determined angiographically at the first (325 ± 90 days) follow-up and between the first and second (772 ± 133 days) follow-ups, respectively, in the Zheng et al. study. In the Kuramitsu et al. study, Early ST was classified as occurring within 30 days, Late ST was between 31 and 365 days, and Very Late ST referred to events after 1 year. * = Multivariate analysis used. Bold text = statistical significance at p < 0.05