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Table 2 Baseline plasma concentrations of apolipoproteins and lipids and the risk of diabetes during follow-up (univariate logistic regression models)

From: Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes

Apolipoproteins

All

(n = 307)

No diabetes

(n1 = 192)

New-onset diabetes

(n2 = 115)

OR (95% CI)

p-value

Data available

(n1/n2)

Total cholesterol (mg/dL)

217 ± 40

218 ± 40

215 ± 40

0.93 (0.74–1.17)

0.5486

191/114

Triglycerides (mg/dL)

119 [86; 167]

108 [83; 154]

137 [94; 173]

1.33 (1.05–1.69)

0.0199*

191/113

LDL-C (mg/dL)

137 ± 36

138 ± 37

136 ± 35

0.96 (0.76–1.21)

0.7202

188/112

HDL-C (mg/dL)

53 ± 15

55 ± 16

50 ± 13

0.79 (0.62–1.00)

0.0461*

191/113

Non-HDL-C (mg/dL)

164 ± 41

164 ± 42

164 ± 38

1.03 (0.82–1.31)

0.7794

191/113

ApoA-I (mg/dL)

123 [106; 143]

124 [106; 144]

122 [106; 142]

0.93 (0.74–1.17)

0.5269

192/115

ApoA-II (mg/dL)

22.7 [19.1; 27.9]

22.3 [19.1; 27.8]

23.4 [19.2; 28.1]

1.08 (0.86–1.36)

0.5158

192/115

ApoA-IV (mg/dL)

8.4 [6.3; 10.8]

8.4 [6.4; 10.8]

8.5 [5.9; 10.7]

0.99 (0.79–1.25)

0.9469

192/115

ApoB100 (mg/dL)

56.0 [43.5; 71.2]

56.5 [45.0; 71.7]

53.7 [41.9; 68.9]

0.94 (0.75–1.19)

0.6266

192/115

ApoC-I (mg/dL)

1.12 [0.92; 1.44]

1.12 [0.89; 1.38]

1.13 [0.94; 1.53]

1.17 (0.93–1.47)

0.1766

192/115

ApoC-II (mg/dL)

2.63 [1.92; 3.48]

2.46 [1.88; 3.48]

2.84 [2.08; 3.62]

1.35 (1.06–1.70)

0.0133*

192/115

ApoC-III (mg/dL)

6.22 [4.91; 8.01]

6.04 [4.88; 7.51]

6.73 [5.23; 9.22]

1.27 (1.01–1.61)

0.0430*

192/115

ApoC-IV (mg/dL)

0.0 [0.0; 0.12]

0.0 [0.0; 0.13]

0.0 [0.0; 0.11]

1.03 (0.82–1.29)

0.8204

192/115

ApoD (mg/dL)

2.88 [2.37; 3.55]

2.98 [2.43; 3.65]

2.78 [2.35; 3.30]

0.86 (0.68–1.09)

0.2026

192/115

ApoE (mg/dL)

6.96 [5.61; 8.61]

6.45 [5.44; 8.35]

7.61 [6.11; 9.14]

1.31 (1.04–1.66)

0.0232*

192/115

ApoF (mg/dL)

0.82 [0.46; 1.20]

0.79 [0.46; 1.14]

0.90 [0.48; 1.36]

1.22 (0.96–1.53)

0.0994

192/115

ApoH (mg/dL)

4.66 [3.95; 5.52]

4.47 [3.88; 5.42]

4.77 [4.14; 5.94]

1.25 (0.98–1.58)

0.0670

192/115

ApoJ (mg/dL)

7.96 [6.66; 9.44]

7.83 [6.66; 9.26]

8.43 [6.65; 9.77]

1.26 (1.00–1.60)

0.0502

192/115

ApoL1 (mg/dL)

1.12 [0.92; 1.35]

1.09 [0.91; 1.28]

1.20 [0.95; 1.52]

1.43 (1.13–1.81)

0.0032**

192/115

ApoM (mg/dL)

1.85 [1.50; 2.32]

1.85 [1.55; 2.33]

1.85 [1.45; 2.28]

0.91 (0.71–1.16)

0.4447

192/115

Apo(a) (nmol/L)

22.7 [0.0; 62.4]

22.8 [0.0; 60.9]

21.9 [0.0; 64.1]

1.02 (0.81–1.29)

0.8685

192/115

  1. Quantitative parameters are expressed as the mean ± SD in the case of Gaussian distribution, otherwise as the median [25th percentile; 75th percentile]. OR are calculated per 1 SD using univariate logistic regression models. The associated p-value is calculated using Wald test (*p < 0.05; **p < 0.01). LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; OR: odds ratio; CI: confidence interval