Tofogliflozin group | Conventional group | Treatment effect (tofogliflozin-conventional treatment) mean change (95% CI), P value | P value between groups | |
---|---|---|---|---|
Mean GSM-CCA | ||||
Baseline | 38.07 ± 12.49 (n = 168) | 38.42 ± 14.19 (n = 169) | 0.81 | |
Week 52 | 38.09 ± 12.01 | 39.49 ± 14.29 | 0.35 | |
Week 104 | 37.32 ± 12.86 | 38.63 ± 14.80 | 0.42 | |
Change at Week 52 | − 0.38 ± 12.02 | 1.03 ± 11.58 | − 1.40 (− 4.03, 1.23), P = 0.30 | |
Change at Week 104 | − 0.98 ± 11.15 | 0.26 ± 11.90 | − 1.24 (− 3.87, 1.38), P = 0.35 | |
Right GSM-CCA | ||||
Baseline | 37.91 ± 14.36 (n = 168) | 37.90 ± 15.82 (n = 169) | 0.99 | |
Week 52 | 38.01 ± 14.21 | 39.37 ± 17.12 | 0.45 | |
Week 104 | 36.06 ± 13.84 | 38.33 ± 15.75 | 0.19 | |
Change at Week 52 | − 0.07 ± 16.25 | 1.45 ± 17.47 | − 1.52 (− 5.29, 2.26), P = 0.43 | |
Change at Week 104 | − 1.80 ± 14.35 | 0.52 ± 15.22 | − 2.33 (− 5.70, 1.05), P = 0.18 | |
Left GSM-CCA | ||||
Baseline | 38.06 ± 13.93 (n = 166) | 38.94 ± 15.44 (n = 169) | 0.58 | |
Week 52 | 38.26 ± 13.27 | 39.50 ± 16.22 | 0.46 | |
Week 104 | 38.48 ± 15.24 | 38.84 ± 16.53 | 0.85 | |
Change at Week 52 | − 0.40 ± 13.66 | 0.44 ± 13.6 | − 0.85(− 3.84,2.14), P = 0.58 | |
Change at Week 104 | − 0.06 ± 14.50 | 0.23 ± 13.81 | − 0.29 (− 3.53, 2.95), P = 0.86 | |
Right GSM-lesion | ||||
Baseline | 47.53 ± 25.71 (n = 99) | 48.43 ± 22.65 (n = 109) | 0.79 | |
Week 52 | 48.55 ± 26.02 | 48.93 ± 24.42 | 0.92 | |
Week 104 | 46.70 ± 24.00 | 49.92 ± 24.12 | 0.36 | |
Change at Week 52 | 1.33 ± 24.69 | − 0.83 ± 25.66 | 2.15 (− 5.20, 9.50), P = 0.56 | |
Change at Week 104 | 0.37 ± 27.09 | 2.01 ± 28.34 | − 1.64 (− 10.01, 6.73), P = 0.70 | |
Left GSM-lesion | ||||
Baseline | 47.93 ± 23.29 (n = 107) | 48.24 ± 23.96 (n = 111) | 0.92 | |
Week 52 | 50.76 ± 27.66 | 46.30 ± 24.60 | 0.23 | |
Week 104 | 47.83 ± 22.64 | 47.65 ± 21.48 | 0.95 | |
Change at Week 52 | 4.31 ± 25.42 | − 2.68 ± 25.85 | 6.99 (− 0.34, 14.32), P = 0.06 | |
Change at Week 104 | 1.33 ± 21.36 | − 0.14 ± 22.96 | 1.47 (− 4.98, 7.92), P = 0.65 | |
Common mean-IMT-CCA | ||||
Baseline | 0.87 ± 0.16 (n = 168) | 0.86 ± 0.15 (n = 169) | 0.93 | |
Week 52 | 0.79 ± 0.14 | 0.78 ± 0.13 | 0.76 | |
Week 104 | 0.74 ± 0.14 | 0.72 ± 0.13 | 0.48 | |
Change at Week 52 | − 0.085 ± 0.071§ | − 0.085 ± 0.067§ | 0.001 (− 0.012, 0.015), P = 0.84 | |
Change at Week 104 | − 0.136 ± 0.091§ | − 0.142 ± 0.080§ | 0.008 (− 0·009, 0·025), P = 0.35 | |
Right mean-IMT-CCA | ||||
Baseline | 0.84 ± 0.15 (n = 168) | 0.85 ± 0.15 (n = 169) | 0.84 | |
Week 52 | 0.77 ± 0.13 | 0.77 ± 0.14 | 0.96 | |
Week 104 | 0.72 ± 0.13 | 0.72 ± 0.14 | 0.76 | |
Change at Week 52 | − 0.074 ± 0.076§ | − 0.077 ± 0.074§ | 0.003 (0.013, 0.018), P = 0.74 | |
Change at Week 104 | − 0.124 ± 0.092§ | − 0.131 ± 0.086§ | 0.007 (0.011, 0.025), P = 0.46 | |
Left mean-IMT-CCA | ||||
Baseline | 0.89 ± 0.20 (n = 168) | 0.88 ± 0.19 (n = 169) | 0.76 | |
Week 52 | 0.80 ± 0.18 | 0.79 ± 0.17 | 0.66 | |
Week 104 | 0.75 ± 0.19 | 0.73 ± 0.17 | 0.38 | |
Change at week 52 | − 0.096 ± 0.107§ | − 0.094 ± 0.092§ | 0.001 (0.019, 0.020), P = 0.95 | |
Change at week 104 | − 0.148 ± 0.127§ | − 0.153 ± 0.107§ | 0.010 (0.013, 0.033), P = 0.41 |