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Table 4 Joint effects between cardiovascular risk factors and diabetes for risk of lower extremity amputation for chronic limb-threatening ischemia via two-by-two table: Cox proportional hazards regression analysis

From: Diabetes and other vascular risk factors in association with the risk of lower extremity amputation in chronic limb-threatening ischemia: a prospective cohort study

 

No diabetes

Diabetes

Cases

HR (95% CI)

Cases

HR (95% CI)

Hypertension

 No hypertension

226

1.00

205

16.10 (13.27–19.53)

 Hypertension

84

1.34 (1.04–1.73)

141

12.07 (9.62–15.16)

Body mass index

 < 23.0 kg/m2

118

1.00

132

19.33 (14.98–24.95)

 ≥ 23.0 kg/m2

192

1.58 (1.25–1.99)

214

16.92 (13.36–21.43)

Smoking

 Never or former smoker

222

1.00

276

13.45 (11.17–16.19)

 Current smoker

88

1.44 (1.11–1.87)

70

19.12 (14.47–25.26)

  1. Cox Model: Hazard ratio (HR) adjusted for age at recruitment, year of study enrolment, sex, dialect group, educational level, physical activity, body mass index, smoking, alcohol consumption, history of hypertension, history of coronary artery disease, history of stroke