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Table 3 Association between cardiovascular risk factors and risk of lower extremity amputation for chronic limb-threatening ischemia stratified by history of diabetes: Cox proportional hazards regression analysis

From: Diabetes and other vascular risk factors in association with the risk of lower extremity amputation in chronic limb-threatening ischemia: a prospective cohort study

 

All subjects

No diabetes

Diabetes

P for interaction

Cases

HR (95% CI)a

HR (95% CI)b

Cases

HR (95% CI)a

Cases

HR (95% CI)b

Hypertension

0.0006

 No hypertension

431

1.00

1.00

226

1.00

205

1.00

 

 Hypertension

225

1.45 (1.22–1.72)

0.95 (0.79–1.13)

84

1.34 (1.04–1.73)

141

0.79 (0.63–1.00)

Body mass index

0.0002

 < 23.0 kg/m2

250

1.00

1.00

118

1.00

132

1.00

 

 ≥ 23.0 kg/m2

406

1.38 (1.17–1.62)

1.17 (0.99–1.37)

192

1.58 (1.25–1.99)

214

0.89 (0.71–1.11)

Smoking

0.84

 Never smoker

408

1.00

1.00

189

1.00

219

1.00

 

 Former smoker

90

1.15 (0.89–1.49)

1.07 (0.83–1.38)

33

0.93 (0.62–1.39)

57

1.16 (0.84–1.62)

 Current smoker

158

1.40 (1.13–1.73)

1.46 (1.19–1.80)

88

1.51 (1.12–2.03)

70

1.42 (1.06–1.91)

Alcohol

0.88

 Never/monthly

584

1.00

1.00

267

1.00

317

1.00

 

 Weekly/daily

72

0.96 (0.74–1.24)

1.08 (0.84–1.40)

43

1.11 (0.79–1.55)

29

1.06 (0.72–1.58)

  1. aCox Model 2: Hazard ratio (HR) adjusted for age at recruitment, year of study enrolment, sex, dialect group, educational level, physical activity, body mass index, smoking, alcohol consumption, history of hypertension, history of coronary artery disease, history of stroke
  2. bCox Model 3: Model 2 plus history of diabetes