Fig. 3
From: Fetuin-A and risk of diabetes-related vascular complications: a prospective study
Stratified associations between pre-diagnostic fetuin-A and incident diabetes-related complications. A P for interaction with sex p = 0.18 for complications overall, p = 0.18 for microvascular and p = 0.56 for macrovascular complications. B P for interaction with baseline glucose (glucose ≥ 100 mg/dL vs glucose < 100 mg/dL) p = 0.85 for complications overall, p = 0.67 with microvascular and p = 0.31 for macrovascular complications. C P for interaction with FLI (FLI < 60 vs FLI ≥ 60) p = 0.94 for complications overall, p = 0.65 for microvascular complications. D P for interaction with baseline fasting status (fasted vs non-fasted) p = 0.36 for complications overall and p = 0.57 with microvascular complications. E P for interaction with baseline eGFR (eGFR ≥ 80 mL/min/1.73 m2 vs < 80 mL/min/1.73 m2) p = 0.10 for complications overall, p = 0.15 for microvascular complications. There were not enough macrovascular events in the subgroups with baseline eGFR < 80 mL/min/1.73 m2, FLI < 60 and fasted subgroup to perform the analysis. Associations were assessed by Cox proportional hazards models and are shown per one unit SD increase (0.06 g/L) in pre-diagnostic fetuin-A concentrations. Models are adjusted for age at diabetes diagnosis (underlying time scale), duration between recruitment and diabetes diagnosis, sex, education (three categories: no or in vocational training, vocational training/technical school, technical college or university), alcohol intake (six categories: < 6.1 g/day, 6.1–12.0 g/day, 12.1–24.0 g/day, 24.1–60.0 g/day, 60.1–96.0 g/day, > 96.0 g/day), smoking (four categories: never smoker, former smoker, current smoker < 20 cigarettes/day, current heavy smoker ≥ 20 cigarettes/day), physical activity (sports ≤ 4 h/week, sports > 4 h/week, biking < 2.5 h/week, biking 2.5–4.9 h/week, biking ≥ 5 h/week), body mass index, waist circumference, history of hypertension, hyperlipidemia, antihypertensive and lipid lowering medications at the time of recruitment. HR, hazard ratio; CI, confidence interval; SD, standard deviation; eGFR, estimated glomerular filtration rate; FLI, fatty liver index