Fig. 2

Associations of pre-diagnosis fetuin-A concentrations with risks of diabetes-related vascular complications. Restricted cubic splines showing the shape of dose–response curve according to baseline fetuin-A concentration: hazard ratios (solid lines) with corresponding 95% CI (shaded area) for total vascular (A), microvascular (B), and macrovascular complications (C). The reference point is median fetuin-A concentration with knots placed at the 5th, 50th, and 95th percentiles. All models were adjusted for age at diabetes diagnosis (underlying time scale), duration between recruitment and diabetes diagnosis, sex, education, alcohol intake, physical activity, BMI, waist circumference, history of hypertension, hyperlipidemia, antihypertensive and lipid lowering medications at the time of recruitment