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Table 4 Risk of VTE according to HbA1c levels measured within 90 days prior to the index date (i.d.)

From: Association between glycemic control and risk of venous thromboembolism in diabetic patients: a nested case–control study

 

Number of cases (%)

Number of controls (%)

Unadjusted ORs

(95% CI)

Adjusted ORs*

(95% CI)

HbA1c level < 90 days prior to i.d. overall

 ≤ 6.5%

278 (22.9)

1345 (28.6)

1.00 (0.81–1.23)

1.04 (0.84–1.30)

 > 6.5–7.0%

161 (13.3)

789 (16.8)

1 (reference)

1 (reference)

 > 7.0–7.5%

172 (14.2)

616 (13.1)

1.40 (1.10–1.78)

1.44 (1.11–1.87)

 > 7.5–8.0%

108 (8.9)

380 (8.1)

1.43 (1.10–1.88)

1.46 (1.09–1.94)

 > 8.0–9.0%

132 (10.9)

394 (8.4)

1.69 (1.30–2.19)

1.64 (1.23–2.17)

 > 9.0%

140 (11.5)

460 (9.8)

1.50 (1.17–1.92)

1.32 (1.01–1.73)

 No Recording**

222 (18.3)

716 (15.2)

1.75 (1.36–2.23)

1.78 (1.38–2.31)

HbA1c level < 90 days prior to i.d. in women

 ≤ 6.5%

155 (11.0)

746 (13.3)

0.99 (0.74–1.34)

1.03 (0.75–1.40)

 > 6.5–7.0%

82 (5.8)

417 (7.4)

1 (reference)

1 (reference)

 > 7.0–7.5%

99 (7.0)

335 (6.0)

1.47 (1.05–2.06)

1.55 (1.08–2.24)

 > 7.5–8.0%

51 (3.6)

192 (3.4)

1.36 (0.92–2.01)

1.43 (0.93–2.18)

 > 8.0–9.0%

66 (4.7)

208 (3.7)

1.50 (1.04–2.15)

1.36 (0.91–2.03)

 > 9.0%

79 (5.6)

239 (4.2)

1.61 (1.13–2.29)

1.47 (0.99–2.17)

 No Recording**

876 (62.2)

3495 (62.1)

1.94 (1.39–2.71)

1.98 (1.40–2.81)

HbA1c level < 90 days prior to i.d. in men

 ≤ 6.5%

125 (10.0)

614 (12.3)

1.00 (0.75–1.34)

1.04 (0.76–1.43)

 > 6.5–7.0%

81 (6.5)

379 (7.6)

1 (reference)

1 (reference)

 > 7.0–7.5%

76 (6.1)

292 (5.9)

1.32 (0.93–1.86)

1.35 (0.91–1.99)

 > 7.5–8.0%

58 (4.7)

191 (3.8)

1.50 (1.04–2.17)

1.48 (0.99–2.22)

 > 8.0–9.0%

67 (5.4)

186 (3.7)

1.93 (1.33–2.80)

1.94 (1.28–2.96)

 > 9.0%

62 (5.0)

226 (4.5)

1.37 (0.96–1.95)

1.23 (0.83–1.82)

 No Recording**

776 (62.3)

3092 (62.1)

1.50 (1.04–2.17)

1.56 (1.04–2.34)

  1. *Adjusted for BMI (categorical), smoking (categorical), CHF, IHD, MI, stroke, hypertension, osteoarthritis, and use of insulin, bisphosphonate, systemic corticosteroids, low-dose acetylsalicylic acid, current and past use of metformin, and current and past use of sulfonylureas
  2. **Included are patients with missing HbA1c measurements as well as those with a last HbA1c level recorded > 90 days prior to the index date