Skip to main content

Table 2 Risk of VTE by HbA1c level

From: Association between glycemic control and risk of venous thromboembolism in diabetic patients: a nested case–control study

HbA1c-level

Number of cases (%)

Number of controls (%)

Unadjusted ORs

(95% CI)

Adjusted ORs*

(95% CI)

HbA1c-Values (last measurement before the index date) and risk of VTE

 ≤ 6.5% (≤ 48 mmol/mol)

843 (31.8)

3809 (35.9)

0.98 (0.87–1.10)

0.98 (0.87–1.10)

 > 6.5–7.0% (> 48– 53 mmol/mol)

441 (16.6)

1963 (18.5)

1 (reference)

1 (reference)

 > 7.0–7.5% (> 53– 58 mmol/mol)

397 (15.0)

1522 (14.3)

1.17 (1.02–1.34)

1.13 (0.98–1.30)

 > 7.5–8.0% (> 58– 64 mmol/mol)

208 (7.8)

839 (7.9)

1.13 (0.95–1.33)

1.09 (0.92–1.29)

 > 8.0–9.0% (> 64– 75 mmol/mol)

253 (9.5)

834 (7.9)

1.38 (1.18–1.61)

1.30 (1.10–1.52)

 > 9.0% (> 75 mmol/mol))

289 (10.9)

929 (8.8)

1.45 (1.24–1.69)

1.18 (1.00–1.40)

 No Recording

222 (8.4)

716 (6.8)

1.54 (1.28–1.85)

1.56 (1.29–1.88)

HbA1c-Values (last measurement before the index date) and risk of VTE in women

 ≤ 6.5% (≤ 48 mmol/mol)

468 (33.2)

2106 (37.4)

1.04 (0.89–1.22)

1.05 (0.89–1.23)

 > 6.5–7.0% (> 48– 53 mmol/mol)

220 (15.6)

1035 (18.4)

1 (reference)

1 (reference)

 > 7.0–7.5% (> 53– 58 mmol/mol)

211 (15.0)

809 (14.4)

1.24 (1.03–1.50)

1.16 (0.95–1.41)

 > 7.5–8.0% (> 58– 64 mmol/mol)

102 (7.2)

422 (7.5)

1.16 (0.92–1.47)

1.15 (0.90–1.48)

 > 8.0–9.0% (> 64– 75 mmol/mol)

122 (8.7)

411 (7.3)

1.43 (1.15–1.79)

1.29 (1.02–1.63)

 > 9.0% (> 75 mmol/mol))

154 (10.9)

456 (8.10)

1.68 (1.36–2.09)

1.36 (1.07–1.72)

 No Recording

131 (9.3)

393 (7.0)

1.81 (1.42–2.31)

1.87 (1.46–2.40)

HbA1c-Values (last measurement before the index date) and risk of VTE in men

 ≤ 6.5% (≤ 48 mmol/mol)

375 (30.1)

1703 (34.2)

0.92 (0.78–1.09)

0.91 (0.77–1.08)

 > 6.5–7.0% (> 48– 53 mmol/mol)

221 (17.8)

928 (18.6)

1 (reference)

1 (reference)

 > 7.0–7.5% (> 53– 58 mmol/mol)

186 (14.9)

713 (14.3)

1.10 (0.91–1.34)

1.10 (0.90–1.34)

 > 7.5–8.0% (> 58–64 mmol/mol)

106 (8.5)

417 (8.4)

1.09 (0.86–1.37)

1.03 (0.81–1.30)

 > 8.0–9.0% (> 64–75 mmol/mol)

131 (10.5)

423 (8.5)

1.33 (1.07–1.65)

1.29 (1.03–1.62)

 > 9.0% (> 75 mmol/mol))

135 (10.8)

473 (9.5)

1.24 (0.99–1.55)

1.03 (0.81–1.30)

No Recording

91 (7.3)

323 (6.5)

1.26 (0.95–1.66)

1.24 (0.93–1.66)

  1. *Adjusted for BMI (categorical), smoking (categorical), CHF, IHD, MI, stroke, hypertension, osteoarthritis, and use of insulin, bisphosphonate, systemic corticosteroids, low-dose acetylsalicylic acid, current and past use of metformin, and current and past use of sulfonylureas