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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Diet-induced weight loss in obese/diabetic mice normalizes glucose metabolism and promotes functional recovery after stroke

Fig. 6

Pre-stroke T2D and dietary change leading to weight loss do not significantly alter vessel density after tMCAO. a CD31+ vessel density in contralateral striatum and infarct core (ipsilateral striatum) after tMCAO. b CD31+ vessel density in the infarct border (ipsilateral striatum) after tMCAO. Data are presented as mean ± SD. Two-way ANOVA (a) or Brown–Forsythe and Welch ANOVA (b) followed by two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli was used for analyses. * Denotes p < 0.05. c Representative images of CD31+ vessel staining in the ipsilateral striatum of non-T2D, T2D/Ob and T2D/WL mice after tMCAO. White solid lines indicate the infarct region (infarct region is on right side of the solid line; peri-infarct region is on left side of the solid line). White dotted lines delineate the infarct border region that was analyzed in figure (b). Scale bar: 100 µm. Group sizes: a, b non-T2D n = 7, T2D/Ob n = 6, T2D/WL n = 6

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