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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Diet-induced weight loss in obese/diabetic mice normalizes glucose metabolism and promotes functional recovery after stroke

Fig. 3

Dietary change leading to weight loss normalizes T2D-induced neuroinflammatory changes after tMCAO. a Iba-1 expression in striatum after sham surgery. b Iba-1 expression in contralateral striatum after tMCAO surgery. c Iba-1 expression in ipsilateral striatum after tMCAO surgery. d CD68 expression in ipsilateral striatum after tMCAO surgery. Data are presented as mean ± SD. Brown–Forsythe and Welch ANOVA followed by two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli was used for all analyses. * Denotes p < 0.05, ** denotes p < 0.01. e Representative images of Iba-1 staining in ipsilateral striatum after tMCAO (left panel), with corresponding examples of thresholded images (right panel). Scale bar: 250 µm. f Representative images of CD68 staining in ipsilateral striatum after tMCAO. Black arrows indicate CD68+ cells and red arrows indicate hematoxylin+ cells. Scale bar: 25 µm. Group sizes: a non-T2D n = 5, T2D/Ob n = 4, T2D/WL n = 4. b, c Non-T2D n = 7, T2D/Ob n = 5, T2D/WL n = 6. d Non-T2D n = 6, T2D/Ob n = 6, T2D/WL n = 6

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