Fig. 2

Effects of dietary change on weight, metabolic parameters and functional recovery after tMCAO. a–c Effect of HFD feeding on body weight (a), fasting glucose (b) and insulin sensitivity (c), Study 1. l–n Effect of HFD feeding on body weight (l), fasting glucose (m) and insulin sensitivity (n), Study 2. d–f Effect of short-term dietary change on body weight (d), fasting glucose (e) and insulin sensitivity (f), Study 1. o–q Effect of long-term dietary change on body weight (o), fasting glucose (p) and insulin sensitivity (q), Study 2. g, h Forepaw grip strength after stroke shown as a plotted curve (g) and AUC (h), Study 1. r, s Forepaw grip strength after stroke shown as a plotted curve (r) and AUC (s), t Corridor task, Study 2. Dashed lines on g, r and t indicate the range of pre-stroke grip strength (g, r) and Corridor task (t). i–k Body weight (i), fasting glucose (j) and insulin sensitivity (k) after tMCAO, Study 1. u–w Body weight (u), fasting glucose (v) and insulin sensitivity (w) after tMCAO, Study 2. Data are presented as mean ± SD. a–c, l–n Welch’s t-test. d–f, o–p, h, s Brown–Forsythe and Welch ANOVA followed by Dunnett’s T3 multiple comparisons test. g, r, t, i, u Two-way repeated measures ANOVA followed by Tukey’s multiple comparisons test. j, k, v, w Two-way ANOVA followed by Tukey’s multiple comparisons test. */$/# denotes p < 0.05, **/$$/## denotes p < 0.01, ***/$$$ denotes p < 0.001 and ****/$$$$ denotes p < 0.0001. Group sizes: a, b non-T2D n = 10, T2D/Ob n = 25. c Non-T2D n = 10, T2D/Ob n = 15. d, e Non-T2D n = 10, T2D/Ob n = 10, T2D/WL n = 15. f Non-T2D n = 9, T2D/Ob n = 10, T2D/WL n = 10. g–k Non-T2D n = 9, T2D/Ob n = 9, T2D/WL n = 13. l–n Non-T2D n = 14, T2D/Ob n = 33. o–q Non-T2D n = 10, T2D/Ob n = 10, T2D/WL n = 15. r–w Non-T2D n = 7, T2D/Ob n = 6, T2D/WL n = 6