| |
n
|
Case
|
Person-years
|
IR*
|
Age and sex adjusted model
|
Multivariate model 1
|
Multivariate model 2
|
|---|
|
HR (95% CI)†
|
p value
|
HR (95% CI)†
|
p value
|
HR (95% CI)†
|
p value
|
|---|
|
All-cause mortality
| | | | | | | | | | |
|
HDL-C variability
|
10,583
|
1838
|
67,271.91
|
27.32
|
1.35 (1.28, 1.43)
|
< 0.001
|
1.31 (1.23, 1.38)
|
< 0.001
|
1.30 (1.22, 1.37)
|
< 0.001
|
|
LDL-C variability
|
10,583
|
1838
|
67,271.91
|
27.32
|
1.07 (1.03, 1.11)
|
< 0.001
|
1.04 (1.00, 1.08)
|
0.04
|
1.05 (1.01, 1.09)
|
0.02
|
|
TG variability
|
10,583
|
1838
|
67,271.91
|
27.32
|
1.05 (1.02, 1.07)
|
0.001
|
1.01 (0.98, 1.04)
|
0.72
|
1.01 (0.98, 1.04)
|
0.56
|
|
TC variability
|
10,583
|
1838
|
67,271.91
|
27.32
|
1.12 (1.06, 1.19)
|
< 0.001
|
1.09 (1.03, 1.16)
|
0.005
|
1.10 (1.03, 1.16)
|
0.003
|
|
Expanded CVD mortality
| | | | | | | | | |
|
HDL-C variability
|
10,583
|
809
|
67,271.91
|
12.03
|
1.33 (1.22, 1.45)
|
< 0.001
|
1.28 (1.17, 1.40)
|
< 0.001
|
1.27 (1.16, 1.39)
|
< 0.001
|
|
LDL-C variability
|
10,583
|
809
|
67,271.91
|
12.03
|
1.11 (1.05, 1.18)
|
< 0.001
|
1.08 (1.02, 1.14)
|
0.01
|
1.08 (1.02, 1.15)
|
0.007
|
|
TG variability
|
10,583
|
809
|
67,271.91
|
12.03
|
1.08 (1.03, 1.12)
|
< 0.001
|
1.04 (0.99, 1.08)
|
0.11
|
1.04 (1.00, 1.09)
|
0.06
|
|
TC variability
|
10,583
|
809
|
67,271.91
|
12.03
|
1.22 (1.13, 1.33)
|
< 0.001
|
1.16 (1.07, 1.27)
|
< 0.001
|
1.16 (1.07, 1.27)
|
< 0.001
|
|
Non-expanded CVD mortality
| | | | | | | | |
|
HDL-C variability
|
10,583
|
1029
|
67,271.91
|
15.30
|
1.37 (1.27, 1.47)
|
< 0.001
|
1.32 (1.23, 1.42)
|
< 0.001
|
1.31 (1.22, 1.42)
|
< 0.001
|
|
LDL-C variability
|
10,583
|
1029
|
67,271.91
|
15.30
|
1.04 (0.98, 1.09)
|
0.19
|
1.01 (0.96, 1.07)
|
0.62
|
1.02 (0.97, 1.07)
|
0.51
|
|
TG variability
|
10,583
|
1029
|
67,271.91
|
15.30
|
1.02 (0.98, 1.06)
|
0.31
|
0.98 (0.94, 1.02)
|
0.37
|
0.98 (0.95, 1.03)
|
0.44
|
|
TC variability
|
10,583
|
1029
|
67,271.91
|
15.30
|
1.05 (0.97, 1.13)
|
0.27
|
1.03 (0.95, 1.12)
|
0.46
|
1.04 (0.96, 1.13)
|
0.31
|
- *Number of incident cases per 1,000 person-years
- †For 10% increase in coefficient of variation
- Multivariate model 1 adjusted for age, sex, smoking, alcohol drinking, exercising, body mass index, duration of diabetes, types of diabetes treatment, fasting plasma glucose, hemoglobin A1c, HDL-C, LDL-C, TG and TC
- Multivariate model 2 adjusted for hypertension, dyslipidemia, stroke, coronary artery disease, severe hypoglycemia, peripheral neuropathy, nephropathy, diabetic ketoacidosis, and hyperglycemic hyperosmolar nonketotic coma, in addition to the variables in the first multivariate model
