Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study

Wang, Mu-Cyun; Li, Chia-Ing; Liu, Chiu-Shong; Lin, Chih-Hsueh; Yang, Shing-Yu; Li, Tsai-Chung; Lin, Cheng-Chieh

doi:10.1186/s12933-021-01421-4

Cardiovascular Diabetology

Table 2 Hazard ratios of mortality for blood lipid variability in patients with type 2 diabetes

From: Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study

	n	Case	Person-years	IR*	Age and sex adjusted model		Multivariate model 1		Multivariate model 2
	n	Case	Person-years	IR*	HR (95% CI)†	p value	HR (95% CI)†	p value	HR (95% CI)†	p value
All-cause mortality
HDL-C variability	10,583	1838	67,271.91	27.32	1.35 (1.28, 1.43)	< 0.001	1.31 (1.23, 1.38)	< 0.001	1.30 (1.22, 1.37)	< 0.001
LDL-C variability	10,583	1838	67,271.91	27.32	1.07 (1.03, 1.11)	< 0.001	1.04 (1.00, 1.08)	0.04	1.05 (1.01, 1.09)	0.02
TG variability	10,583	1838	67,271.91	27.32	1.05 (1.02, 1.07)	0.001	1.01 (0.98, 1.04)	0.72	1.01 (0.98, 1.04)	0.56
TC variability	10,583	1838	67,271.91	27.32	1.12 (1.06, 1.19)	< 0.001	1.09 (1.03, 1.16)	0.005	1.10 (1.03, 1.16)	0.003
Expanded CVD mortality
HDL-C variability	10,583	809	67,271.91	12.03	1.33 (1.22, 1.45)	< 0.001	1.28 (1.17, 1.40)	< 0.001	1.27 (1.16, 1.39)	< 0.001
LDL-C variability	10,583	809	67,271.91	12.03	1.11 (1.05, 1.18)	< 0.001	1.08 (1.02, 1.14)	0.01	1.08 (1.02, 1.15)	0.007
TG variability	10,583	809	67,271.91	12.03	1.08 (1.03, 1.12)	< 0.001	1.04 (0.99, 1.08)	0.11	1.04 (1.00, 1.09)	0.06
TC variability	10,583	809	67,271.91	12.03	1.22 (1.13, 1.33)	< 0.001	1.16 (1.07, 1.27)	< 0.001	1.16 (1.07, 1.27)	< 0.001
Non-expanded CVD mortality
HDL-C variability	10,583	1029	67,271.91	15.30	1.37 (1.27, 1.47)	< 0.001	1.32 (1.23, 1.42)	< 0.001	1.31 (1.22, 1.42)	< 0.001
LDL-C variability	10,583	1029	67,271.91	15.30	1.04 (0.98, 1.09)	0.19	1.01 (0.96, 1.07)	0.62	1.02 (0.97, 1.07)	0.51
TG variability	10,583	1029	67,271.91	15.30	1.02 (0.98, 1.06)	0.31	0.98 (0.94, 1.02)	0.37	0.98 (0.95, 1.03)	0.44
TC variability	10,583	1029	67,271.91	15.30	1.05 (0.97, 1.13)	0.27	1.03 (0.95, 1.12)	0.46	1.04 (0.96, 1.13)	0.31

^*Number of incident cases per 1,000 person-years
^†For 10% increase in coefficient of variation
Multivariate model 1 adjusted for age, sex, smoking, alcohol drinking, exercising, body mass index, duration of diabetes, types of diabetes treatment, fasting plasma glucose, hemoglobin A1c, HDL-C, LDL-C, TG and TC
Multivariate model 2 adjusted for hypertension, dyslipidemia, stroke, coronary artery disease, severe hypoglycemia, peripheral neuropathy, nephropathy, diabetic ketoacidosis, and hyperglycemic hyperosmolar nonketotic coma, in addition to the variables in the first multivariate model

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