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Table 2 Hazard ratios of mortality for blood lipid variability in patients with type 2 diabetes

From: Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study

  n Case Person-years IR* Age and sex adjusted model Multivariate model 1 Multivariate model 2
HR (95% CI)† p value HR (95% CI)† p value HR (95% CI)† p value
All-cause mortality           
 HDL-C variability 10,583 1838 67,271.91 27.32 1.35 (1.28, 1.43)  < 0.001 1.31 (1.23, 1.38)  < 0.001 1.30 (1.22, 1.37)  < 0.001
 LDL-C variability 10,583 1838 67,271.91 27.32 1.07 (1.03, 1.11)  < 0.001 1.04 (1.00, 1.08) 0.04 1.05 (1.01, 1.09) 0.02
 TG variability 10,583 1838 67,271.91 27.32 1.05 (1.02, 1.07) 0.001 1.01 (0.98, 1.04) 0.72 1.01 (0.98, 1.04) 0.56
 TC variability 10,583 1838 67,271.91 27.32 1.12 (1.06, 1.19)  < 0.001 1.09 (1.03, 1.16) 0.005 1.10 (1.03, 1.16) 0.003
Expanded CVD mortality          
 HDL-C variability 10,583 809 67,271.91 12.03 1.33 (1.22, 1.45)  < 0.001 1.28 (1.17, 1.40)  < 0.001 1.27 (1.16, 1.39)  < 0.001
 LDL-C variability 10,583 809 67,271.91 12.03 1.11 (1.05, 1.18)  < 0.001 1.08 (1.02, 1.14) 0.01 1.08 (1.02, 1.15) 0.007
 TG variability 10,583 809 67,271.91 12.03 1.08 (1.03, 1.12)  < 0.001 1.04 (0.99, 1.08) 0.11 1.04 (1.00, 1.09) 0.06
 TC variability 10,583 809 67,271.91 12.03 1.22 (1.13, 1.33)  < 0.001 1.16 (1.07, 1.27)  < 0.001 1.16 (1.07, 1.27)  < 0.001
Non-expanded CVD mortality         
 HDL-C variability 10,583 1029 67,271.91 15.30 1.37 (1.27, 1.47)  < 0.001 1.32 (1.23, 1.42)  < 0.001 1.31 (1.22, 1.42)  < 0.001
 LDL-C variability 10,583 1029 67,271.91 15.30 1.04 (0.98, 1.09) 0.19 1.01 (0.96, 1.07) 0.62 1.02 (0.97, 1.07) 0.51
 TG variability 10,583 1029 67,271.91 15.30 1.02 (0.98, 1.06) 0.31 0.98 (0.94, 1.02) 0.37 0.98 (0.95, 1.03) 0.44
 TC variability 10,583 1029 67,271.91 15.30 1.05 (0.97, 1.13) 0.27 1.03 (0.95, 1.12) 0.46 1.04 (0.96, 1.13) 0.31
  1. *Number of incident cases per 1,000 person-years
  2. For 10% increase in coefficient of variation
  3. Multivariate model 1 adjusted for age, sex, smoking, alcohol drinking, exercising, body mass index, duration of diabetes, types of diabetes treatment, fasting plasma glucose, hemoglobin A1c, HDL-C, LDL-C, TG and TC
  4. Multivariate model 2 adjusted for hypertension, dyslipidemia, stroke, coronary artery disease, severe hypoglycemia, peripheral neuropathy, nephropathy, diabetic ketoacidosis, and hyperglycemic hyperosmolar nonketotic coma, in addition to the variables in the first multivariate model