Patients with stable coronary artery disease and type 2 diabetes but without prior myocardial infarction or stroke and THEMIS-like patients: real-world prevalence and risk of major outcomes from the SNDS French nationwide claims database

Blin, Patrick; Darmon, Patrice; Henry, Patrick; Guiard, Estelle; Bernard, Marie-Agnès; Dureau-Pournin, Caroline; Maizi, Hélène; Thomas-Delecourt, Florence; Lassalle, Régis; Droz-Perroteau, Cécile; Moore, Nicholas

doi:10.1186/s12933-021-01416-1

Cardiovascular Diabetology

Table 5 Factors Associated with the composite outcome in the three study populations multivariate Cox proportional hazards risk model, selection threshold HR ≥ 1.20 or HR ≤ 0.80, adjusted on PCI and CABG 5-year history)

From: Patients with stable coronary artery disease and type 2 diabetes but without prior myocardial infarction or stroke and THEMIS-like patients: real-world prevalence and risk of major outcomes from the SNDS French nationwide claims database

	CAD-T2DM population without prior MI or stroke n = 258,260			THEMIS-like population n = 64,334			PCI THEMIS-like population n = 11,622
	No	Yes	HR [95% CI]	No	Yes	HR [95% CI]	No	Yes	HR [95% CI]
Male^a	148,849	27,558	1.25 [1.22–1.27]	37,396	4842	1.31 [1.25–1.38]	7902	791	1.14 [0.99–1.31]
Age (in years)
< 55	11,412	712	1.00	2334	102	1.00	460	22	1.00
55–59	15,739	1210	1.18 [1.08–1.29]	4757	225	1.04 [0.82–1.31]	908	45	0.98 [0.59–1.63]
60–64	27,295	2502	1.37 [1.26–1.49]	7794	483	1.34 [1.08–1.66]	1561	117	1.42 [0.90–2.23]
65–69	37,571	4244	1.64 [1.51–1.77]	10,421	758	1.53 [1.24–1.88]	2089	133	1.19 [0.76–1.87]
70–74	34,402	4804	1.95 [1.80–2.11]	9143	857	1.92 [1.56–2.36]	1818	151	1.52 [0.97–2.37]
75–79	35,768	6698	2.49 [2.30–2.69]	8946	1164	2.55 [2.09–3.13]	1677	198	2.00 [1.29–3.12]
80–84	31,106	8954	3.51 [3.25–3.79]	7438	1536	3.78 [3.09–4.62]	1267	204	2.54 [1.63–3.95]
85–89	16,767	7687	5.07 [4.69–5.48]	4066	1453	5.98 [4.88–7.31]	577	165	4.13 [2.64–6.47]
≥ 90	6373	5016	7.74 [7.15–8.38]	1713	1144	9.88 [8.06–12.1]	166	64	5.10 [3.12–8.32]
PCI within the 5-year history	62,072	9504	0.88 [0.86–0.90]	10,555	1102	0.86 [0.81–0.92]		11,622	–
CABG within the 5-year history	1544	316	0.95 [0.85–1.06]	304	31	0.73 [0.51–1.04]		0	–
Within the 1-year history
Heart failure^b	15,240	7783	1.77 [1.73–1.82]	2278	892	1.79 [1.67–1.92]	316	105	2.05 [1.67–2.52]
Cancer^b	26,547	9521	1.67 [1.63–1.71]	6777	1728	1.70 [1.61–1.79]	1166	249	1.84 [1.59–2.12]
Liver diseases^{b, c}	5176	1882	1.80 [1.72–1.89]	580	82	1.16 [0.93–1.44]	78	14	1.64 [0.96–2.78]
Peripheral arterial disease^b	20,657	6996	1.56 [1.52–1.61]	2957	799	1.72 [1.59–1.85]	561	149	2.21 [1.85–2.63]
Neurotic and mood disorders^b	11,996	3377	1.29 [1.25–1.34]	3221	660	1.33 [1.23–1.45]	393	66	1.47 [1.14–1.89]
Within the 2-year follow-up
Diuretics^d			1.49 [1.46–1.52]			1.44 [1.37–1.51]			1.62 [1.42–1.85]
Antiplatelet agent^d			1.03 [1.01–1.06]			1.29 [1.13–1.46]			1.24 [0.96–1.60]
Antidiabetic treatment^d
Monotherapy			1.00			1.00			1.00
No antidiabetic treatment			0.72 [0.69–0.75]			0.72 [0.65–0.80]			0.82 [0.60–1.11]
Bitherapy			0.69 [0.65–0.72]			0.70 [0.63–0.79]			0.80 [0.57–1.13]
Tritherapy or more			0.65 [0.60–0.70]			0.67 [0.56–0.79]			0.73 [0.45–1.17]
Insulin			1.27 [1.21–1.32]			1.20 [1.08–1.34]			1.41 [1.03–1.93]

PCI, percutaneous coronary intervention; CABG, coronary artery bypass graft
^aReference is female
^bReference is non-presence of variable
^cExcluding chronic viral hepatitis/cystic fibrosis
^dTime dependent variables during follow-up

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