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Table 2 Relation between hs-CRP and cardiovascular events and mortality in tertiles of hs-CRP

From: Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes

Tertiles of log(hs-CRP)

Tertile 1

Tertile 2

Tertile 3

n = 1679

n = 558

n = 561

n = 560

Range hs-CRP, mgl/L

0.13–1.35

1.35–3.22

3.22–9.97

Myocardial infarction

 n

41

53

62

 Model I

1.00 (ref)

1.22 (0.81–1.83)

1.46 (0.98–2.18)

 Model II

1.00 (ref)

0.91 (0.59–1.39)

1.07 (0.70–1.63)

 Model III

1.00 (ref)

0.87 (0.57–1.32)

1.23 (0.81–1.85)

Stroke

 n

24

33

28

 Model I

1.00 (ref)

1.28 (0.76–1.17)

1.12 (0.76–2.17)

 Model II

1.00 (ref)

0.96 (0.55–1.68)

0.81 (0.45–1.47)

 Model III

1.00 (ref)

0.71 (0.40–1.22)

0.67 (0.37–1.20)

Cardiovascular events

n

80

102

125

 Model I

1.00 (ref)

1.19 (0.88–1.59)

1.52 (1.14–2.02)

 Model II

1.00 (ref)

0.93 (0.68–1.27)

1.16 (0.85–1.57)

 Model III

1.00 (ref)

0.88 (0.65–1.21)

1.24 (0.91–1.68)

Vascular mortality

 n

38

58

88

 Model I

1.00 (ref)

1.47 (0.98–2.22)

2.34 (1.59–3.43)*

 Model II

1.00 (ref)

1.26 (0.81–1.95)

1.87 (1.23–2.84)*

 Model III

1.00 (ref)

1.37 (0.89–2.10)

1.87 (1.22–2.85)*

All-cause mortality

 n

74

113

156

 Model I

1.00 (ref)

1.47 (1.09–1.97)*

2.11 (1.59–2.79)*

 Model II

1.00 (ref)

1.26 (0.92–1.72)

1.72 (1.27–2.33)*

 Model III

1.00 (ref)

1.34 (0.98–1.84)

1.89 (1.39–2.57)*

  1. hsCRP per tertiles, T1 = ref, hazard ratio (95% confidence interval); *statistically significant p < 0.05
  2. Model I: age + sex
  3. Model II: Model I + BMI, smoking, alcohol, non-HDL-c, micro-albuminuria
  4. Model III: Model II + lipid-lowering therapy, aspirin