Fig. 1From: Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and managementPathophysiological mechanisms of cardiomyopathy in type 2 diabetes (CMiPD). Fatty acids (FAs) are preferentially metabolized to ATP, sustaining muscle contraction. During progression to severe stages of cardiomyopathy, both the increased FA metabolism and accumulated ceramide contribute to inflammation and fibrosis, leading to cardiac stiffness and reduced contractilityBack to article page