Skip to main content

Table 2 Three-year clinical outcome of patients with normoglycemia, prediabetes or diabetes

From: Impact of prediabetes and diabetes on 3-year outcome of patients treated with new-generation drug-eluting stents in two large-scale randomized clinical trials

  Normo-glycemia
n=2353
Prediabetes
n=489
Diabetes
n=1488
Prediabetes vs. Normoglycemia Diabetes vs. Normoglycemia
Unadjusted Adjusted Unadjusted Adjusted
HR
(95 % CI)
p-value HR (95 %CI) p-value HR
(95 % CI)
p-value HR
(95 % CI)
p-value
Target vessel failure 142 (6.1) 54 (11.2) 197 (13.7) 1.89 (1.38–2.58) < 0.001 1.79 (1.31–2.45) < 0.001 2.30 (1.85–2.86) < 0.001 2.03 (1.63–2.52) < 0.001
Any death 80 (3.4) 26 (5.4) 112 (7.7) 1.59 (1.02–2.47) 0.04 1.54 (0.99–2.40) 0.06 2.3 (1.72–3.05) < 0.001 2.11 (1.58–2.82) < 0.001
 Cardiac death 26 (1.1) 15 (3.1) 49 (3.4) 2.81 (1.49–5.30) 0.001 2.70 (1.43–5.10) 0.002 3.1 (1.91–4.94) < 0.001 2.76 (1.71–4.45) < 0.001
Any MI 72 (3.1) 23 (4.8) 87 (6.1) 1.56 (0.98–2.49) 0.06 1.49 (0.93–2.38) 0.10 2.0 (1.45–2.70) < 0.001 1.77 (1.29–2.42) < 0.001
 Target vessel MI 57 (2.5) 17 (3.6) 65 (4.5) 1.45 (0.84–2.49) 0.18 1.36 (0.79–2.33) 0.27 1.84 (1.29–2.63) 0.001 1.59 (1.11–2.28) 0.011
Any revascularization 159 (6.9) 55 (11.6) 195 (13.8) 1.72 (1.27–2.34) 0.001 1.66 (1.22–2.25) 0.001 2.07 (1.68–2.56) < 0.001 1.88 (1.52–2.32) < 0.001
 Target vessel revascularization 85 (3.7) 33 (7.0) 118 (8.4) 1.92 (1.29–2.87) 0.001 1.81 (1.21–2.71) 0.004 2.31 (1.75–3.06) < 0.001 2.05 (1.55–2.71) < 0.001
  Target lesion revascularization 49 (2.1) 26 (5.5) 78 (5.5) 2.62 (1.63–4.22) < 0.001 2.48 (1.54–4.00) < 0.001 2.63 (1.84–3.76) < 0.001 2.33 (1.62–3.34) < 0.001
Target lesion failure 115 (5.0) 49 (10.2) 159 (11.0) 2.11 (1.51–2.94) < 0.001 2.01 (1.44–2.80) < 0.001 2.28 (1.79–2.89) < 0.001 2.00 (1.57–2.55) < 0.001
MACE 179 (7.7) 63 (13.0) 235 (16.0) 1.75 (1.31–2.33) < 0.001 1.69 (1.27–2.25) < 0.001 2.19 (1.80–2.66) < 0.001 1.98 (1.62–2.40) < 0.001
Definite-or-probable stent thrombosis 10 (0.4) 5 (1.1) 23 (1.6) 2.43 (0.83–7.10) 0.11 2.30 (0.79–6.75) 0.13 3.73 (1.77–7.83) 0.001 3.35 (1.58–7.09) 0.002
 Definite stent thrombosis 9 (0.4) 2 (0.4) 14 (1.0) 1.08 (0.23–4.99) 0.92 1.03 (0.22–4.78) 0.97 2.52 (1.09–5.82) 0.030 2.30 (0.99–5.37) 0.053
Bleeding 96 (4.2) 28 (5.9) 93 (6.5) 1.43 (0.94–2.18) 0.09 1.32 (0.83–2.09) 0.24 1.59 (1.19–2.11) 0.001 1.19 (0.85–1.67) 0.32
 Major Bleeding 53 (2.3) 19 (3.9) 59 (4.1) 1.76 (1.04–3.98) 0.034 1.60 (0.89–2.91) 0.12 1.81(1.25–2.63) 0.002 1.35 (0.89–2.12) 0.20
  1. Values are n (%)
  2. MI, myocardial infarction; MACE, major adverse cardiac events