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Table 4 Hazard ratios for the primary outcome and death from any Cause in prespecified Subgroups

From: Atherogenic index of plasma is associated with major adverse cardiovascular events in patients with type 2 diabetes mellitus

Outcome

Low AIP

High AIP

HRa

95% CI

P

P for interactionb

Events/n

%

Events/n

%

MACEs

 Sex

0.024

  Male

389/2207

17.63

874/4092

21.36

1.230

1.091–1.386

0.001

 

  Female

204/1832

11.14

359/2120

16.93

1.566

1.318–1.859

 < 0.001

 

 Age

0.912

  < 65

298/2416

12.33

690/4073

16.94

1.426

1.245–1.634

 < 0.001

 

  ≥ 65

295/1623

18.18

543/2139

25.39

1.410

1.224–1.625

 < 0.001

 

 Race/ethnicity

0.557

  White

336/1987

16.91

929/4406

21.08

1.286

1.135–1.457

 < 0.001

 

  Non-white

257/2052

12.52

304/1806

16.83

1.368

1.159–1.615

 < 0.001

 

 CVD history

0.254

  Yes

300/1260

23.81

669/2349

28.48

1.241

1.083–1.422

0.002

 

  No

293/2779

10.54

564/3863

14.60

1.391

1.208–1.602

 < 0.001

 

 Glycemia arm

0.716

  Standard

301/2021

14.89

629/3102

20.28

1.408

1.227–1.615

 < 0.001

 

  Intensive

292/2018

14.47

604/3110

19.42

1.358

1.181–1.562

 < 0.001

 

 Trail

0.131

  BP

311/2295

13.55

468/2438

19.20

1.473

1.277–1.700

 < 0.001

 

  Lipid

282/1744

16.17

765/3774

20.27

1.263

1.102–1.448

0.001

 

 HbA1c

0.072

  < 8.0

243/1971

12.33

548/2898

18.91

1.553

1.335–1.806

 < 0.001

 

  ≥ 8.0

350/2068

16.92

685/3314

2067

1.260

1.108–1.433

 < 0.001

 

 Depression

0.257

  Yes

122/802

15.21

363/1619

22.42

1.519

1.238–1.865

 < 0.001

 

  No

470/3235

14.53

870/4593

18.94

1.325

1.184–1.482

 < 0.001

 

Nonfatal myocardial infarction

 Sex

0.064

  Male

190/2207

8.61

457/4092

11.17

1.318

1.112–1.561

0.001

 

  Female

97/1832

5.29

192/2120

9.06

1.747

1.369–2.230

 < 0.001

 

 Age

0.761

  < 65

146/2416

6.04

373/4073

9.16

1.566

1.293–1.896

 < 0.001

 

  ≥ 65

141/1623

8.69

276/2139

12.90

1.498

1.223–1.835

 < 0.001

 

 Race/ethnicity

0.648

  White

170/1987

8.56

501/4406

11.37

1.362

1.144–1.621

 < 0.001

 

  Non-white

117/2052

5.7

148/1806

8.19

1.462

1.147–1.864

0.002

 

 CVD history

0.158

  Yes

152/1260

12.06

356/2349

15.16

1.287

1.064–1.555

0.009

 

  No

135/2779

4.86

293/3863

7.58

1.572

1.282–1.928

 < 0.001

 

 Glycemia arm

0.891

  Standard

151/2021

7.47

341/3102

10.99

1.513

1.249–1.832

 < 0.001

 

  Intensive

136/2018

6.74

308/3110

9.90

1.485

1.214–1.817

 < 0.001

 

 Trail

0.025

  BP

143/2295

6.23

257/2438

10.54

1.747

1.424–2.144

 < 0.001

 

  Lipid

144/1744

8.26

392/3774

10.39

1.266

1.046–1.532

0.016

 

 HbA1c

0.600

  < 8.0

112/1779

6.30

255/2602

9.80

1.568

1.255–1.958

 < 0.001

 

  ≥ 8.0

175/2260

7.74

394/3610

10.91

1.450

1.214–1.733

 < 0.001

 

 Depression

0.203

  Yes

61/802

7.61

208/1619

12.85

1.729

1.300–2.300

 < 0.001

 

  No

226/3235

6.99

441/4593

9.60

1.394

1.188–1.637

 < 0.001

 
  1. aLow AIP as a reference, the Hazard Ratio of High AIP for the primary outcome or nonfatal myocardial infarction in each subgroup in sex, age, race/ethnicity, CVD history, glycemia arm, trial, HbA1c, and depression
  2. bInteraction between categorical factor AIP and sex, age, race/ethnicity, CVD history, glycemia arm, trial, HbA1c, and depression, respectively
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Cardiovascular Diabetology

ISSN: 1475-2840