Outcome
|
Low AIP
|
High AIP
|
HRa
|
95% CI
|
P
|
P for interactionb
|
---|
Events/n
|
%
|
Events/n
|
%
|
---|
MACEs
|
Sex
|
0.024
|
Male
|
389/2207
|
17.63
|
874/4092
|
21.36
|
1.230
|
1.091–1.386
|
0.001
| |
Female
|
204/1832
|
11.14
|
359/2120
|
16.93
|
1.566
|
1.318–1.859
|
< 0.001
| |
Age
|
0.912
|
< 65
|
298/2416
|
12.33
|
690/4073
|
16.94
|
1.426
|
1.245–1.634
|
< 0.001
| |
≥ 65
|
295/1623
|
18.18
|
543/2139
|
25.39
|
1.410
|
1.224–1.625
|
< 0.001
| |
Race/ethnicity
|
0.557
|
White
|
336/1987
|
16.91
|
929/4406
|
21.08
|
1.286
|
1.135–1.457
|
< 0.001
| |
Non-white
|
257/2052
|
12.52
|
304/1806
|
16.83
|
1.368
|
1.159–1.615
|
< 0.001
| |
CVD history
|
0.254
|
Yes
|
300/1260
|
23.81
|
669/2349
|
28.48
|
1.241
|
1.083–1.422
|
0.002
| |
No
|
293/2779
|
10.54
|
564/3863
|
14.60
|
1.391
|
1.208–1.602
|
< 0.001
| |
Glycemia arm
|
0.716
|
Standard
|
301/2021
|
14.89
|
629/3102
|
20.28
|
1.408
|
1.227–1.615
|
< 0.001
| |
Intensive
|
292/2018
|
14.47
|
604/3110
|
19.42
|
1.358
|
1.181–1.562
|
< 0.001
| |
Trail
|
0.131
|
BP
|
311/2295
|
13.55
|
468/2438
|
19.20
|
1.473
|
1.277–1.700
|
< 0.001
| |
Lipid
|
282/1744
|
16.17
|
765/3774
|
20.27
|
1.263
|
1.102–1.448
|
0.001
| |
HbA1c
|
0.072
|
< 8.0
|
243/1971
|
12.33
|
548/2898
|
18.91
|
1.553
|
1.335–1.806
|
< 0.001
| |
≥ 8.0
|
350/2068
|
16.92
|
685/3314
|
2067
|
1.260
|
1.108–1.433
|
< 0.001
| |
Depression
|
0.257
|
Yes
|
122/802
|
15.21
|
363/1619
|
22.42
|
1.519
|
1.238–1.865
|
< 0.001
| |
No
|
470/3235
|
14.53
|
870/4593
|
18.94
|
1.325
|
1.184–1.482
|
< 0.001
| |
Nonfatal myocardial infarction
|
Sex
|
0.064
|
Male
|
190/2207
|
8.61
|
457/4092
|
11.17
|
1.318
|
1.112–1.561
|
0.001
| |
Female
|
97/1832
|
5.29
|
192/2120
|
9.06
|
1.747
|
1.369–2.230
|
< 0.001
| |
Age
|
0.761
|
< 65
|
146/2416
|
6.04
|
373/4073
|
9.16
|
1.566
|
1.293–1.896
|
< 0.001
| |
≥ 65
|
141/1623
|
8.69
|
276/2139
|
12.90
|
1.498
|
1.223–1.835
|
< 0.001
| |
Race/ethnicity
|
0.648
|
White
|
170/1987
|
8.56
|
501/4406
|
11.37
|
1.362
|
1.144–1.621
|
< 0.001
| |
Non-white
|
117/2052
|
5.7
|
148/1806
|
8.19
|
1.462
|
1.147–1.864
|
0.002
| |
CVD history
|
0.158
|
Yes
|
152/1260
|
12.06
|
356/2349
|
15.16
|
1.287
|
1.064–1.555
|
0.009
| |
No
|
135/2779
|
4.86
|
293/3863
|
7.58
|
1.572
|
1.282–1.928
|
< 0.001
| |
Glycemia arm
|
0.891
|
Standard
|
151/2021
|
7.47
|
341/3102
|
10.99
|
1.513
|
1.249–1.832
|
< 0.001
| |
Intensive
|
136/2018
|
6.74
|
308/3110
|
9.90
|
1.485
|
1.214–1.817
|
< 0.001
| |
Trail
|
0.025
|
BP
|
143/2295
|
6.23
|
257/2438
|
10.54
|
1.747
|
1.424–2.144
|
< 0.001
| |
Lipid
|
144/1744
|
8.26
|
392/3774
|
10.39
|
1.266
|
1.046–1.532
|
0.016
| |
HbA1c
|
0.600
|
< 8.0
|
112/1779
|
6.30
|
255/2602
|
9.80
|
1.568
|
1.255–1.958
|
< 0.001
| |
≥ 8.0
|
175/2260
|
7.74
|
394/3610
|
10.91
|
1.450
|
1.214–1.733
|
< 0.001
| |
Depression
|
0.203
|
Yes
|
61/802
|
7.61
|
208/1619
|
12.85
|
1.729
|
1.300–2.300
|
< 0.001
| |
No
|
226/3235
|
6.99
|
441/4593
|
9.60
|
1.394
|
1.188–1.637
|
< 0.001
| |
- aLow AIP as a reference, the Hazard Ratio of High AIP for the primary outcome or nonfatal myocardial infarction in each subgroup in sex, age, race/ethnicity, CVD history, glycemia arm, trial, HbA1c, and depression
- bInteraction between categorical factor AIP and sex, age, race/ethnicity, CVD history, glycemia arm, trial, HbA1c, and depression, respectively