|
Age, years*
|
64 (57, 69)
|
64 (56, 72)
|
|
Body mass index, kg/m2*
|
26.7 (24.5, 30.2)
|
26.6 (24.4, 29.3)
|
|
Body surface area, m2*
|
2.0 (1.8, 2.1)
|
1.9 (1.8, 2.1)
|
|
Male sex
|
90
|
96
|
|
Smoking history
|
41
|
46
|
|
Duration of type 2 diabetes, years*
|
10.0 (4.0, 15.0)
|
10.0 (5.0, 15.0)
|
|
Hypertension
|
92
|
90
|
|
History of myocardial infarction
|
39
|
44
|
|
History of percutaneous coronary intervention > 2 months before screening
|
53
|
40
|
|
History of coronary artery bypass surgery > 2 months before screening
|
57
|
56
|
|
History of heart failure
|
4.0
|
8.0
|
|
History of peripheral artery disease
|
4.0
|
6.0
|
|
History of transient ischemic attack or stroke
|
16
|
13
|
|
Serum creatinine, mg/dL*
|
0.9 (0.8, 1.0)
|
0.9 (0.8, 1.0)
|
|
Hemoglobin A1c, %*
|
7.9 (7.5, 8.4)
|
7.9 (7.3, 8.7)
|
|
Hematocrit, %*
|
0.42 (0.40, 0.46)
|
0.42 (0.39, 0.44)
|
|
Systolic blood pressure, mmHg*
|
128 (120, 143)
|
134 (125, 146)
|
|
Diastolic blood pressure, mmHg*
|
74 (69, 82)
|
77 (71, 81)
|
|
Heart rate, bpm*
|
67 (60, 77)
|
68 (60, 76)
|
|
Cardiac MRI data
| | |
|
Left ventricular mass, g
|
116.5 (26.3)
|
120.9 (33.0)
|
|
Left ventricular mass index, g/m2
|
59.3 (10.9)
|
62.2 (12.8)
|
|
Left ventricular end diastolic volume index, mL/m2
|
63.3 (15.5)
|
71.4 (15.4)
|
|
Left ventricular end systolic volume index. mL/m2
|
27.1 (10.5)
|
32.3 (11.8)
|
|
Left ventricular ejection fraction. %
|
58.0 (7.5)
|
55.5 (8.7)
|
|
Echocardiographic data
| | |
|
Right ventricular systolic pressure, mmHg†
|
22.8 (6.5)
|
20.7 (4.4)
|
|
Peak tricuspid regurgitation velocity, m/s†
|
2.2 (0.38)
|
2.1 (0.27)
|
|
Tricuspid annular plane systolic excursion, cm
|
2.0 (1.2)
|
1.8 (0.5)
|
|
Right ventricular S’, mm
|
10.4 (2.7)
|
10.9 (2.9)
|
|
Biomarkers
| | |
|
NT-pro B-type natriuretic peptide, pg/mL*
|
97.0 (46.0, 190)
|
116 (59.0, 230)
|
|
High sensitivity troponin I, ng/mL*
|
0.03 (0.03, 0.20)
|
0.03 (0.03, 0.03)
|
|
Medications at baseline
| | |
|
Aspirin/P2Y12 inhibitor
|
82
|
85
|
|
Beta blocker
|
78
|
81
|
|
Calcium channel blocker
|
12
|
31
|
|
Angiotensin converting enzyme inhibitor/angiotensin receptor blocker
|
82
|
85
|
|
Statin
|
96
|
96
|
|
Insulin
|
25
|
25
|
|
Metformin
|
96
|
92
|
