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Table 2 Biochemical measurements that mediated the effect of dulaglutide on MACE-multi factor analysis

From: Exploring potential mediators of the cardiovascular benefit of dulaglutide in type 2 diabetes patients in REWIND

  HbA1c (%) and UACR (mg/mmol)
HRa (95% CI) of dulaglutide on MACE
(after adjusting for the baseline and updated mean value of the variable)
0.957 (0.838, 1.093)
Percentage mediated by updated mean towards the effect of dulaglutide on MACEa 65.4
HRa (95% CI) of dulaglutide on MACE
(after adjusting for the baseline and change from baseline value of the variable)
0.929 (0.815, 1.060)
Percentage mediated by change from baseline towards the effect of dulaglutide on MACEa 41.7
  1. CI confidence interval; HR hazard ratio, MACE major adverse cardiovascular event, UACR urine albumin/creatinine ratio
  2. aCalculated from a Cox proportional hazards regression model using time-dependent explanatory variables