Table 2 Biochemical measurements that mediated the effect of dulaglutide on MACE-multi factor analysis

HR^a (95% CI) of dulaglutide on MACE

(after adjusting for the baseline and updated mean value of the variable)

0.957 (0.838, 1.093)

Percentage mediated by updated mean towards the effect of dulaglutide on MACE^a

65.4

HR^a (95% CI) of dulaglutide on MACE

(after adjusting for the baseline and change from baseline value of the variable)

0.929 (0.815, 1.060)

Percentage mediated by change from baseline towards the effect of dulaglutide on MACE^a

41.7