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Table 3 Determinants of LV contractile dysfunction in women with HFpEF

From: Effect of diabetes mellitus on the development of left ventricular contractile dysfunction in women with heart failure and preserved ejection fraction

  GLS GCS GRS
  Univariable Multivariable Univariable Multivariable Univariable Multivariable
  β p-value β p-value β p-value β p-value β p-value β p-value
Age#, yrs 0.53 < 0.001 0.26 0.027 0.41 < 0.001 0.22 0.035 − 0.31 0.005 -0.25 0.041
Obesity& 0.23 0.039    0.08 0.490    − 0.16 0.156   
PP#, mmHg 0.09 0.421    0.06 0.611    0.02 0.889   
HT 0.08 0.481    0.14 0.207    − 0.11 0.335   
DM 0.49 < 0.001 0.26 0.007 0.39 < 0.001 0.31 < 0.001 − 0.31 0.007 − 0.24 0.016
CAD 0.24 0.036    0.21 0.066    − 0.08 0.503   
NT-proBNP*, pg/mL 0.30 0.007 0.21 0.028 0.27 0.016 0.17 0.095 − 0.39 < 0.001 − 0.32 0.002
eGFR, mL/min/1.73m2 − 0.09 0.423    0.01 0.910    0.03 0.787   
LVM, g 0.41 0.001 0.20 0.042 0.35 0.007 0.27 0.020 − 0.40 0.002 − 0.28 0.007
  1. β is adjusted regression coefficient. Variables with bold font indicate statistical significance in multivariable analysis
  2. #Changes in dependent variables per 10 units increase
  3. &Subjects with body mass index ≥ 25 kg/m2 were classified as obese group that proposed by the World Health Organization for Asian populations
  4. *NT-proBNP is log-transformed before being included in the regression analysis
  5. LV: left ventricular; HFpEF: heart failure with preserved ejection fraction; GLS: global longitudinal strain; GCS: global circumferential strain; GRS: global radial strain; PP: pulse pressure; HT: hypertension; DM: diabetes mellitus; CAD: coronary artery disease; NT-proBNP: amino-terminal pro-B-type natriuretic peptide; eGFR: estimated glomerular filtration rate; LVM: left ventricular mass