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Table 3 Determinants of LV contractile dysfunction in women with HFpEF

From: Effect of diabetes mellitus on the development of left ventricular contractile dysfunction in women with heart failure and preserved ejection fraction

 

GLS

GCS

GRS

 

Univariable

Multivariable

Univariable

Multivariable

Univariable

Multivariable

 

β

p-value

β

p-value

β

p-value

β

p-value

β

p-value

β

p-value

Age#, yrs

0.53

< 0.001

0.26

0.027

0.41

< 0.001

0.22

0.035

− 0.31

0.005

-0.25

0.041

Obesity&

0.23

0.039

  

0.08

0.490

  

− 0.16

0.156

  

PP#, mmHg

0.09

0.421

  

0.06

0.611

  

0.02

0.889

  

HT

0.08

0.481

  

0.14

0.207

  

− 0.11

0.335

  

DM

0.49

< 0.001

0.26

0.007

0.39

< 0.001

0.31

< 0.001

− 0.31

0.007

− 0.24

0.016

CAD

0.24

0.036

  

0.21

0.066

  

− 0.08

0.503

  

NT-proBNP*, pg/mL

0.30

0.007

0.21

0.028

0.27

0.016

0.17

0.095

− 0.39

< 0.001

− 0.32

0.002

eGFR, mL/min/1.73m2

− 0.09

0.423

  

0.01

0.910

  

0.03

0.787

  

LVM, g

0.41

0.001

0.20

0.042

0.35

0.007

0.27

0.020

− 0.40

0.002

− 0.28

0.007

  1. β is adjusted regression coefficient. Variables with bold font indicate statistical significance in multivariable analysis
  2. #Changes in dependent variables per 10 units increase
  3. &Subjects with body mass index ≥ 25 kg/m2 were classified as obese group that proposed by the World Health Organization for Asian populations
  4. *NT-proBNP is log-transformed before being included in the regression analysis
  5. LV: left ventricular; HFpEF: heart failure with preserved ejection fraction; GLS: global longitudinal strain; GCS: global circumferential strain; GRS: global radial strain; PP: pulse pressure; HT: hypertension; DM: diabetes mellitus; CAD: coronary artery disease; NT-proBNP: amino-terminal pro-B-type natriuretic peptide; eGFR: estimated glomerular filtration rate; LVM: left ventricular mass
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Cardiovascular Diabetology

ISSN: 1475-2840