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Table 3 Gene ontology enrichment analysis

From: Basement membrane proteins in various arterial beds from individuals with and without type 2 diabetes mellitus: a proteome study

Artery

Compartment

Regulation in T2DM

GO term

p

Proteins

ATA

–

Up

Basement membrane

0.034

LAMB2, LAMA5, COL5A1, COL18A1, HSPG2, NID2, LAMC1, NID1

Down

Translation

0.007

RPL18, RPS23, GCN1, SLC25A11, RPL18A, SLC25A3, RPS8, RPL32, RPS11, RPS24, RPL21

ITA

Adventitia

Up

Blood microparticle

0.006

ALB, TF, IGHA1, IGHG1

ICA

Media

Up

rRNA binding

0.031

RPL37, RPL8, RPL11, RPS18

Immune response

0.034

IGHV3, C1R, CXCL12, IGKV2-40, THBS1, C8B, C3

Plaque

Up

Membrane attack complex

0.045

C6, C7, C8A, C9

Down

Blood coagulation, fibrin clot formation

0.007

FGA, FGB, FGG

Proteinaceous extracellular matrix

0.038

COL15A1, FBN1, FBLN2, EMILIN2, LUM, WISP2

  1. No gene ontology (GO) terms were enriched in the medial layer of internal thoracic arteries (ITAs), and in the media underlying atherosclerotic plaques in internal carotid arteries (ICAs) among downregulated proteins
  2. ATA: ascending thoracic aorta; ITA: internal thoracic artery; ICA: internal carotid artery; T2DM: Type 2 diabetes mellitus
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Cardiovascular Diabetology

ISSN: 1475-2840