Table 2 Top five significantly regulated proteins in artery tissues/compartments from patients with type 2 diabetes mellitus
Protein name | Accession | Fold change | p | fdr |
|---|---|---|---|---|
Ascending thoracic aorta (ATA) | ||||
 Unconventional myosin-Id (MYO1D) | O94832 | 0.88 | 5.0E−04 | 0.83 |
 Collagen alpha-1(VIII) chain (COL8A1) | P27658 | 0.80 | 1.0E−03 | 1.00 |
 NADH-cytochrome b5 reductase 3 (CYB5R3) | P00387 | 0.89 | 2.1E−03 | 1.00 |
 Prenylcysteine oxidase 1 OS = Homo sapiens (PCYOX1) | Q9UHG3 | 0.91 | 2.5E−03 | 1.00 |
 Trypsin-3 (PRSS3) | P35030 | 1.20 | 2.8E−03 | 1.00 |
Internal thoracic artery (ITA)—Medial layer | ||||
 Unconventional myosin-Ic (MYO1C) | O00159 | 1.18 | 1.3E−02 | 1.00 |
 Desmin (DES) | P17661 | 1.28 | 2.0E−02 | 1.00 |
 Histone H2A (H2AFX) | P16104 | 1.29 | 2.4E−02 | 1.00 |
 Annexin A1(ANXA1) | P04083 | 0.85 | 2.5E−02 | 1.00 |
I soform 2 of Tropomyosin beta chain (TPM2) | P07951-2 | 1.27 | 2.7E−02 | 1.00 |
Internal thoracic artery (ITA)—Adventitial layer | ||||
 Prelamin-A/C (LMNA) | P02545 | 0.84 | 7.9E−03 | 1.00 |
 Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) | O43294 | 0.73 | 1.6E−02 | 1.00 |
 Ig alpha-1 chain C region (IGHA1) | P01876 | 1.42 | 2.7E−02 | 1.00 |
 Microtubule-associated protein 1B (MAP1B) | P46821 | 0.64 | 3.0E−02 | 1.00 |
 Myosin-10 (MYH10) | F8VTL3 | 0.78 | 3.1E−02 | 1.00 |
Internal carotid artery (ICA)—Plaque | ||||
 Plastin-3 (PLS3) | P13797 | 0.50 | 5.3E−04 | 0.83 |
 Immunoglobulin J chain (JCHAIN) | P01591 | 1.98 | 1.0E−03 | 1.00 |
 Guaninenucleotide-binding protein G(i) subunit alpha-2 (GNAI2) | P04899 | 0.75 | 4.4E−03 | 1.00 |
 Insulin-like growth factor II (IGF2) | P01344 | 1.40 | 5.1E−03 | 1.00 |
 Alpha-parvin (PARVA) | Q9NVD7 | 1.81 | 5.2E−03 | 1.00 |
Internal carotid artery (ICA)—Media | ||||
 Isoform 2 of Heterogeneous nuclear ribonucleoprotein K (HNRNPK) | P61978-2 | 1.44 | 3.4E−07 | 5.6E−04 |
 60S ribosomal protein L23 (RPL23) | P62829 | 0.29 | 4.4E−05 | 0.07 |
 Ribonuclease 4 (RNASE4) | P34096 | 1.57 | 9.7E−04 | 1.00 |
 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) | Q02809 | 0.50 | 2.0E−03 | 1.00 |
 Calponin-2 (CNN2) | Q99439 | 2.04 | 2.0E−03 | 1.00 |