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Table 1 Patient characteristics

From: Basement membrane proteins in various arterial beds from individuals with and without type 2 diabetes mellitus: a proteome study

Clinical characteristics

Internal thoracic artery (ITA)

Internal carotid artery (ICA)

Ascending thoracic aorta (ATA)

Non-DM

T2DM

p

Non-DM

T2DM

p

Non-DM

T2DM

p

n

7

9

NA

9

10

NA

10

10

NA

Age at surgery (y)

65 ± 12

68 ± 12

0.65

69 ± 5

71 ± 9

0.59

71 ± 8

64 ± 11

0.11

Male sex (%)

7 (100%)

8 (89%)

0.38

8 (80%)

8 (89%)

0.60

10 (100%)

10 (100%)

–

SBP (mmHg)

131 ± 9

139 ± 10

0.20

152 ± 22

148 ± 20

0.71

155 ± 16

142 ± 14

0.09

DBP (mmHg)

73 ± 8

74 ± 6

0.84

77 ± 10

74 ± 10

0.49

79 ± 7

75 ± 8

0.35

BMI (kg/m2)

30 ± 4

37 ± 4

0.01

27 ± 4

28 ± 3

0.35

28 ± 3

31 ± 6

0.18

Comorbidities

 Hypertension, n (%)

6 (86%)

7 (78%)

0.69

5 (50%)

8 (89%)

0.08

7 (70%)

10 (100%)

0.07

 Stroke, n (%)

0 (0%)

0 (0%)

-

5 (50%)

3 (33%)

0.47

0 (0%)

0 (0%)

–

 ACS, n (%)

0 (0%)

1 (11%)

0.38

1 (10%)

1 (11%)

0.95

0 (0%)

0 (0%)

–

 Cancer, n (%)

1 (14%)

1 (11%)

0.86

1 (10%)

1 (11%)

0.95

0 (0%)

0 (0%)

–

 Uraemia, n (%)

0 (0%)

0 (0%)

–

0 (0%)

0 (0%)

–

0 (0%)

0 (0%)

–

 Never smoked, n (%)

2 (29%)

1 (11%)

0.38

3 (30%)

3 (33%)

0.89

4 (40%)

2 (20%)

0.34

Biochemical factors

 HbA1c (mmol/mol)

39.8 ± 4.3

61.7 ± 10.7

 < 0.01

37.7 ± 2.8

54 ± 0.8

 < 0.01

37.1 ± 2.8

63.1 ± 15.6

< 0.01

 Cholesterol (mmol/L)

4.1 ± 0.6

3.6 ± 1.0

0.31

4.3 ± 1.2

3.9 ± 0.3

0.41

4.2 ± 1.3

3.9 ± 1.0

0.60

 LDL (mmol/L)

2.2 ± 0.6

1.9 ± 0.8

0.45

2.7 ± 1.0

2.1 ± 0.3

0.18

2.5 ± 1.3

1.8 ± 0.3

0.22

 HDL (mmol/L)

1.1 ± 0.3

0.9 ± 0.3

0.28

1.2 ± 0.3

1.1 ± 0.3

0.76

1.2 ± 0.3

1.1 ± 0.6

0.86

 Triglyceride (mmol/L)

1.8 ± 1.1

1.8 ± 0.4

0.96

2.1 ± 0.9

1.9 ± 0.8

0.76

1.3 ± 0.2

2.0 ± 0.7

0.06

 Creatinine (mmol/L)

93 ± 19

94 ± 22

0.91

80 ± 17

93 ± 30

0.42

88 ± 14

93 ± 17

0.55

Medication

 Metformin, n (%)

0 (%)

7 (78%)

 < 0.01

0 (%)

7 (78%)

 < 0.01

0 (%)

9 (90%)

< 0.01

 Insulin, n (%)

0 (%)

3 (33%)

0.10

0 (%)

6 (66%)

 < 0.01

0 (%)

0 (%)

–

 Statins, n (%)

6 (86%)

7 (78%)

0.69

6 (60%)

8 (89%)

0.16

9 (90%)

9 (90%)

1.0

 Antihypertensives, n (%)

7 (100%)

9 (100%)

–

6 (60%)

9 (100%)

0.04

8 (80%)

10 (100%)

0.15

 Anticoagulants, n (%)

7 (100%)

8 (89%)

0.38

10 (100%)

9 (100%)

–

1 (10%)

10 (100%)

< 0.01

 Steroids, n (%)

0 (%)

0 (%)

–

0 (%)

0 (%)

–

0 (%)

0 (%)

–

  1. Results are depicted as number (n), percentage (%) or mean ± standard deviation. Student’s t-test was used for continuous variables. Pearson Chi-Square Test was used for dichotomous variables
  2. Non-DM: non-diabetes mellitus; T2DM: type 2 diabetes mellitus; SBP: systolic blood pressure; DBP: Diastolic blood pressure; BMI: Body mass index; ACS: Acute coronary syndrome; HbA1c: Hemoglobin A1c; LDL: Low-density lipoprotein; HDL: High-density lipoprotein; NA: not available