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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Basement membrane proteins in various arterial beds from individuals with and without type 2 diabetes mellitus: a proteome study

Fig. 1

A Summary of samples analysed in the study. B–F Volcano plots showing regulation of all identified proteins in all tissues/compartments. The volcano plots graphically represent the effect of T2DM compared to non-DM on all proteins measured for each tissue type (each dot represents a unique protein). The plots show magnitude of change (fold change, FC) (x-axis) versus statistical significance (y-axis). FCs are ln2-transformed (i.e. upregulated proteins will have a ln2(FC) > 0 and vice versa), and the significance level is shown as the negative logarithm (base 10) of the p value (i.e. proteins with a value above ~ 1.3 have a p < 0.05). Pre-defined basement membrane (BM) proteins are shown as magnified yellow dots. The top 5 most significantly regulated proteins for each tissue/compartment are shown as magnified blue dots along with identities. In E, fibrinogens are shown as magnified red dots with identities. In E, F complement factors are shown as magnified green dots with identities. ATA: ascending thoracic aorta; ITA: internal thoracic artery; ICA: Internal carotid artery

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