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Table 3 Overall mortality according to diabetes therapy in the inverse probability of treatment weighted pseudo-cohort within the KorAHF registry

From: Impact of insulin therapy on the mortality of acute heart failure patients with diabetes mellitus

  Original cohort Weighteda pseudo-cohort
Person-years Death
N
HR (95% CI)b Person-years Death
N
HR (95% CI)b HR (95% CI)c
HbA1c < 7.0%
 OHA-only 725 85 1.00 725 60 1.00 1.00
 Insulin-only 582 110 1.55 (1.16–2.05) 582 110 1.52 (1.11–2.09) 1.64 (1.18–2.28)
HbA1c ≥ 7.0%
 OHA-only 661 102 1.30 (0.98–1.74) 661 71 1.58 (1.12–2.23) 1.69 (1.18–2.42)
 Insulin-only 464 104 1.84 (1.38–2.42) 464 104 1.83 (1.33–2.52) 2.25 (1.61–3.13)
 p-interaction    0.66    0.22 0.20
HbA1c < 7.0%
 Only oral 725 85 1.00 725 97 1.00 1.00
 All insulin 939 179 1.56 (1.20–2.02) 939 179 1.50 (1.17–1.92) 1.59 (1.23–2.05)
HbA1c ≥ 7.0%
 Only oral 661 102 1.30 (0.98–1.74) 661 123 1.52 (1.17–1.99) 1.58 (1.20–2.09)
 All insulin 1153 196 1.42 (1.10–1.83) 1153 196 1.38 (1.08–1.76) 1.57 (1.22–2.02)
 p-interaction    0.05    0.85 < 0.01
  1. N number, HR hazard ratio, CI confidence interval, OHA oral hypoglycemic agents
  2. aInverse probability treatment (IPT)-weighted
  3. bCrude HR (95% CI)
  4. cAdditionally adjusted for age, vasodilators management at admission and ACEIs/ARBs management at dischare in the first pseudo-cohort with 426 OHA group and 682 insulin only group; adjusted for age, hypertension and inotropes and vasodilators management at admission