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Table 3 Overall mortality according to diabetes therapy in the inverse probability of treatment weighted pseudo-cohort within the KorAHF registry

From: Impact of insulin therapy on the mortality of acute heart failure patients with diabetes mellitus

 

Original cohort

Weighteda pseudo-cohort

Person-years

Death

N

HR (95% CI)b

Person-years

Death

N

HR (95% CI)b

HR (95% CI)c

HbA1c < 7.0%

 OHA-only

725

85

1.00

725

60

1.00

1.00

 Insulin-only

582

110

1.55 (1.16–2.05)

582

110

1.52 (1.11–2.09)

1.64 (1.18–2.28)

HbA1c ≥ 7.0%

 OHA-only

661

102

1.30 (0.98–1.74)

661

71

1.58 (1.12–2.23)

1.69 (1.18–2.42)

 Insulin-only

464

104

1.84 (1.38–2.42)

464

104

1.83 (1.33–2.52)

2.25 (1.61–3.13)

 p-interaction

  

0.66

  

0.22

0.20

HbA1c < 7.0%

 Only oral

725

85

1.00

725

97

1.00

1.00

 All insulin

939

179

1.56 (1.20–2.02)

939

179

1.50 (1.17–1.92)

1.59 (1.23–2.05)

HbA1c ≥ 7.0%

 Only oral

661

102

1.30 (0.98–1.74)

661

123

1.52 (1.17–1.99)

1.58 (1.20–2.09)

 All insulin

1153

196

1.42 (1.10–1.83)

1153

196

1.38 (1.08–1.76)

1.57 (1.22–2.02)

 p-interaction

  

0.05

  

0.85

< 0.01

  1. N number, HR hazard ratio, CI confidence interval, OHA oral hypoglycemic agents
  2. aInverse probability treatment (IPT)-weighted
  3. bCrude HR (95% CI)
  4. cAdditionally adjusted for age, vasodilators management at admission and ACEIs/ARBs management at dischare in the first pseudo-cohort with 426 OHA group and 682 insulin only group; adjusted for age, hypertension and inotropes and vasodilators management at admission
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Cardiovascular Diabetology

ISSN: 1475-2840