|
SBP, mmHg
|
|
All patients
|
(n = 107)
|
(n = 113)
|
|
Baseline
|
125.1 (122.1 to 128.2)
|
124.7 (121.8 to 127.7)
|
|
Week 24
|
122.4 (119.3 to 125.4)
|
123.8 (120.8 to 126.8)
|
|
Absolute change from baseline to week 24
|
− 2.74 (− 5.28 to − 0.20)
|
− 0.92 (− 3.39 to 1.55)
|
|
Naïve
|
(n = 38)
|
(n = 43)
|
|
Baseline
|
126.2 (121.4 to 131.0)
|
123.8 (119.3 to 128.4)
|
|
Week 24
|
124.1 (119.3 to 128.9)
|
121.5 (116.9 to 126.0)
|
|
Absolute change from baseline to week 24
|
− 2.03 (− 6.59 to 2.54)
|
− 2.37 (− 6.67 to 1.92)
|
|
Non-naïve
|
(n = 69)
|
(n = 70)
|
|
Baseline
|
124.5 (120.6 to 128.5)
|
125.3 (121.4 to 129.2)
|
|
Week 24
|
121.4 (117.5 to 125.3)
|
125.2 (121.3 to 129.1)
|
|
Absolute change from baseline to week 24
|
− 3.13 (− 6.20 to − 0.06)
|
− 0.03 (− 3.07 to 3.02)
|
|
Non-naïve metformin user
|
(n = 18)
|
(n = 26)
|
|
Baseline
|
121.2 (113.6 to 128.9)
|
122.6 (116.2 to 129.0)
|
|
Week 24
|
120.0 (112.3 to 127.7)
|
122.1 (115.7 to 128.5)
|
|
Absolute change from baseline to week 24
|
− 1.22 (− 7.74 to 5.29)
|
− 0.50 (− 5.92 to 4.92)
|
|
Non-naïve DPP-4 inhibitor user
|
(n = 60)
|
(n = 59)
|
|
Baseline
|
124.5 (120.2 to 128.8)
|
125.0 (120.7 to 129.3)
|
|
Week 24
|
121.0 (116.7 to 125.3)
|
125.5 (121.2 to 129.8)
|
|
Absolute change from baseline to week 24
|
− 3.52 (− 6.78 to − 0.25)
|
0.53 (− 2.77 to 3.82)
|
|
BMI, kg/m2
|
|
All patients
|
(n = 109)
|
(n = 109)
|
|
Baseline
|
25.3 (24.6 to 26.1)
|
25.7 (25.0 to 26.4)
|
|
Week 24
|
24.4 (23.6 to 25.1)
|
25.8 (25.1 to 26.6)
|
|
Absolute change from baseline to week 24
|
− 0.96 (− 1.20 to − 0.72)
|
0.14 (− 0.09 to 0.38)
|
|
Naïve
|
(n = 39)
|
(n = 42)
|
|
Baseline
|
24.4 (23.3 to 25.5)
|
25.3 (24.3 to 26.3)
|
|
Week 24
|
23.5 (22.4 to 24.6)
|
25.4 (24.3 to 26.4)
|
|
Absolute change from baseline to week 24
|
− 0.93 (− 1.33 to − 0.53)
|
0.05 (− 0.33 to 0.44)
|
|
Non-naïve
|
(n = 70)
|
(n = 67)
|
|
Baseline
|
25.8 (24.9 to 26.8)
|
25.9 (24.9 to 26.9)
|
|
Week 24
|
24.9 (23.9 to 25.8)
|
26.1 (25.1 to 27.1)
|
|
Absolute change from baseline to week 24
|
− 0.98 (− 1.29 to − 0.68)
|
0.20 (− 0.11 to 0.51)
|
|
Non-naïve metformin user
|
(n = 18)
|
(n = 25)
|
|
Baseline
|
27.6 (25.6 to 29.6)
|
26.8 (25.1 to 28.5)
|
|
Week 24
|
26.5 (24.5 to 28.5)
|
26.9 (25.2 to 28.6)
|
|
Absolute change from baseline to week 24
|
− 1.14 (− 1.70 to − 0.59)
|
0.09 (− 0.38 to 0.56)
|
|
Non-naïve DPP-4 inhibitor user
|
(n = 61)
|
(n = 56)
|
|
Baseline
|
25.7 (24.6 to 26.7)
|
26.3 (25.2 to 27.4)
|
|
Week 24
|
24.7 (23.6 to 25.7)
|
26.5 (25.4 to 27.6)
|
|
Absolute change from baseline to week 24
|
− 1.01 (− 1.36 to − 0.66)
|
0.21 (− 0.15 to 0.57)
|
|
ePV
|
|
All patients
|
(n = 107)
|
(n = 114)
|
|
Percent change from baseline to week 24, %
|
− 5.22 (− 7.66 to − 2.78)
|
1.11 (− 1.25 to 3.47)
|
|
Naïve
|
(n = 38)
|
(n = 45)
|
|
Percent change from baseline to week 24, %
|
− 5.80 (− 9.97 to − 1.63)
|
− 0.17 (− 4.00 to 3.66)
|
|
Non-naïve
|
(n = 69)
|
(n = 69)
|
|
Percent change from baseline to week 24, %
|
− 4.90 (− 7.94 to − 1.86)
|
1.95 (− 1.09 to 4.99)
|
|
Non-naïve metformin user
|
(n = 17)
|
(n = 26)
|
|
Percent change from baseline to week 24, %
|
− 6.53 (− 11.69 to − 1.38)
|
1.86 (− 2.31 to 6.03)
|
|
Non-naïve DPP-4 inhibitor user
|
(n = 61)
|
(n = 58)
|
|
Percent change from baseline to week 24, %
|
− 4.08 (− 7.33 to − 0.83)
|
1.77 (− 1.57 to 5.11)
|
