Skip to main content

Table 3 Impact of risk factors for cerebrovascular disease according to prior cerebrovascular disease and glucose status

From: Impact of prior cerebrovascular disease and glucose status on incident cerebrovascular disease in Japanese

 

Prior CVD (-)

     

Prior CVD ( +)

     

Normoglycemia

 

Border

 

Diabetes

 

Normoglycemia

 

Border

 

Diabetes

 

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Age (per/y increase)

1.08 (1.07–1.09)

 < 0.001

1.08 (1.07–1.09)

 < 0.001

1.06 (1.05–1.08)

 < 0.001

1.02 (0.99–1.05)

0.122

1.03 (1.00–1.06)

0.025

1.03 (0.99–1.06)

0.125

Current smoking (yes/no)

1.48 (1.31–1.68)

 < 0.001

1.54 (1.35–1.75)

 < 0.001

1.54 (1.29–1.82)

 < 0.001

1.23 (0.73–2.08)

0.436

0.98 (0.60–1.59)

0.927

1.32 (0.81–2.16)

0.261

BMI

 Per 5 kg/m2 increase

1.10 (0.98–1.23)

0.093

1.09 (0.98–1.21)

0.109

0.95 (0.84–1.06)

0.335

1.02 (0.69–1.52)

0.914

0.92 (0.66–1.28)

0.604

1.03 (0.78–1.37)

0.819

 Per 1 SD increase

1.07 (0.99–1.15)

 

1.06 (0.99–1.14)

 

0.96 (0.89–1.04)

 

1.02 (0.77–1.33)

 

0.94 (0.75–1.18)

 

1.02 (0.85–1.24)

 

Systolic blood pressure

 Per 10 mmHg increase

1.36 (1.31–1.41)

 < 0.001

1.32 (1.27–1.37)

 < 0.001

1.23 (1.18–1.29)

 < 0.001

1.00 (0.85–1.18)

0.965

1.18 (1.04–1.34)

0.012

1.27 (1.12–1.44)

 < 0.001

 Per 1 SD increase

1.58 (1.50–1.68)

 

1.51 (1.43–1.59)

 

1.37 (1.28–1.46)

 

1.01 (0.79–1.28)

 

1.27 (1.05–1.54)

 

1.43 (1.19–1.72)

 

LDL cholesterol

 Per 1 mmol/L increase

0.98 (0.90–1.06)

0.606

0.97 (0.90–1.06)

0.511

0.95 (0.86–1.05)

0.333

0.78 (0.58–1.05)

0.096

0.93 (0.72–1.21)

0.600

0.95 (0.74–1.21)

0.664

 Per 1 SD increase

0.98 (0.92–1.05)

 

0.98 (0.92–1.04)

 

0.96 (0.89–1.04)

 

0.82 (0.65–1.04)

 

0.95 (0.77–1.16)

 

0.96 (0.79–1.17)

 

HDL cholesterol

 Per 1 mmol/L increase

0.82 (0.69–0.98)

0.028

0.79 (0.66–0.95)

0.013

0.68 (0.52–0.88)

0.003

0.94 (0.51–1.74)

0.843

0.70 (0.39–1.28)

0.245

1.48 (0.79–2.76)

0.224

 Per I SD increase

0.93 (0.87–0.99)

 

0.91 (0.85–0.98)

 

0.86 (0.78–0.95)

 

0.98 (0.77–1.24)

 

0.87 (0.70–1.10)

 

1.16 (0.91–1.47)

 

HbA1c

 Per 1 mmol/mol increase

0.98 (0.96–1.01)

0.190

1.02 (1.00–1.04)

0.090

1.01 (1.01–1.02)

 < 0.001

0.96 (0.88–1.04)

0.327

1.02 (0.96–1.09)

0.477

1.01 (0.99–1.02)

0.359

 Per I SD increase

0.88 (0.73–1.06)

 

1.14 (0.98–1.32)

 

1.08 (1.04–1.13)

 

0.71 (0.36–1.40)

 

1.18 (0.74–1.88)

 

1.06 (0.94–1.19)

 
  1. Each variable for CVD adjusted for age, current smoking, BMI, systolic blood pressure, LDL cholesterol, HDL cholesterol, and HbA1c. Border, borderline glycemia; CVD, cerebrovascular disease; HR, hazard ratio; P, p-value; SD, standard deviation
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840